HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"recordsFiltered": 49482,
"recordsTotal": 49482,
"next": "http://staging-fdaaa.ebmdatalab.net/api/trials/?format=api&length=300&ordering=-sponsor__name&start=46500",
"previous": "http://staging-fdaaa.ebmdatalab.net/api/trials/?format=api&length=300&ordering=-sponsor__name&start=45900",
"results": [
{
"registry_id": "NCT06986174",
"publication_url": "https://clinicaltrials.gov/study/NCT06986174",
"title": "A Phase 2 Study to Evaluate the Safety and Efficacy of Pacritinib in Relapsed or Refractory Waldenström Macroglobulinemia",
"has_exemption": false,
"start_date": "2025-11-21",
"completion_date": "2028-10-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Shayna Sarosiek, MD",
"sponsor_slug": "shayna-sarosiek-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06408246",
"publication_url": "https://clinicaltrials.gov/study/NCT06408246",
"title": "Accelerating Cognition-guided Signatures to Enhance Translation in Depression Aim 3: Clinical Cognitive Trial",
"has_exemption": false,
"start_date": "2026-03-03",
"completion_date": "2028-10-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06962657",
"publication_url": "https://clinicaltrials.gov/study/NCT06962657",
"title": "Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection",
"has_exemption": false,
"start_date": "2026-05-15",
"completion_date": "2028-10-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Diego",
"sponsor_slug": "university-of-california-san-diego",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07434843",
"publication_url": "https://clinicaltrials.gov/study/NCT07434843",
"title": "PEMIGIST: Phase 2 Study of Pemigatinib (INCB054828) in the Treatment of Patients With Advanced SDH-deficient Gastrointestinal Stromal Tumor (GIST)",
"has_exemption": false,
"start_date": "2026-05-19",
"completion_date": "2028-10-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Dana-Farber Cancer Institute",
"sponsor_slug": "dana-farber-cancer-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07013591",
"publication_url": "https://clinicaltrials.gov/study/NCT07013591",
"title": "Randomized Clinical Trial of β Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery",
"has_exemption": false,
"start_date": "2026-06-10",
"completion_date": "2028-10-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Brigham and Women's Hospital",
"sponsor_slug": "brigham-and-womens-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06833008",
"publication_url": "https://clinicaltrials.gov/study/NCT06833008",
"title": "An Open-label, Phase I/II First-in-human, Dose Escalation and Confirmation Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic and Anti-tumour Activity of IPN01195 as Single Agent in Adult Participants With Advanced Solid Tumours",
"has_exemption": false,
"start_date": "2025-03-14",
"completion_date": "2028-10-03",
"has_results": false,
"results_due": false,
"sponsor_name": "Ipsen",
"sponsor_slug": "ipsen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06202274",
"publication_url": "https://clinicaltrials.gov/study/NCT06202274",
"title": "Clinical Study to Evaluate the Safety and Efficacy of Candela Technology",
"has_exemption": false,
"start_date": "2023-10-04",
"completion_date": "2028-10-04",
"has_results": false,
"results_due": false,
"sponsor_name": "Candela Corporation",
"sponsor_slug": "candela-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06003387",
"publication_url": "https://clinicaltrials.gov/study/NCT06003387",
"title": "Phase 3b, Open-label, Multicenter, Single-dose Study Investigating Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy Administered to Adult Subjects With Severe or Moderately Severe Hemophilia B With Detectable Pretreatment AAV5 Neutralizing Antibodies",
"has_exemption": false,
"start_date": "2024-01-30",
"completion_date": "2028-10-04",
"has_results": false,
"results_due": false,
"sponsor_name": "CSL Behring",
"sponsor_slug": "csl-behring",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05835310",
"publication_url": "https://clinicaltrials.gov/study/NCT05835310",
"title": "A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of IV Anifrolumab in Pediatric Participants 5 to < 18 Years of Age With Moderate to Severe Active Systemic Lupus Erythematosus While on Background Standard of Care Therapy",
"has_exemption": false,
"start_date": "2024-03-14",
"completion_date": "2028-10-05",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07288034",
"publication_url": "https://clinicaltrials.gov/study/NCT07288034",
"title": "Immunotherapy Biomarker Collection for Metastatic NSCLC to Inform Adaptive Personalized Models Targeting Resistance (IMMUNO-BIOMAP)",
"has_exemption": false,
"start_date": "2026-04-08",
"completion_date": "2028-10-08",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07668414",
"publication_url": "https://clinicaltrials.gov/study/NCT07668414",
"title": "Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)",
"has_exemption": false,
"start_date": "2026-09-22",
"completion_date": "2028-10-10",
"has_results": false,
"results_due": false,
"sponsor_name": "Novo Nordisk A/S",
"sponsor_slug": "novo-nordisk-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT00801489",
"publication_url": "https://clinicaltrials.gov/study/NCT00801489",
"title": "A Phase 2 Study of Fludarabine, Cytarabine, Filgrastim-sndz,Gemtuzumab Ozogamicin and Idarubicin in Newly Diagnosed Core Binding Factor Associated Acute Myelogenous Leukemia",
"has_exemption": false,
"start_date": "2007-04-04",
"completion_date": "2028-10-11",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT01878617",
"publication_url": "https://clinicaltrials.gov/study/NCT01878617",
"title": "A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma",
"has_exemption": false,
"start_date": "2013-06-23",
"completion_date": "2028-10-13",
"has_results": false,
"results_due": false,
"sponsor_name": "St. Jude Children's Research Hospital",
"sponsor_slug": "st-jude-childrens-research-hospital",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT06492291",
"publication_url": "https://clinicaltrials.gov/study/NCT06492291",
"title": "A Phase 3, Open-label Extension Study to Evaluate the Safety and Efficacy of MK-0616 in Adults With Hypercholesterolemia",
"has_exemption": false,
"start_date": "2024-08-05",
"completion_date": "2028-10-13",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07223047",
"publication_url": "https://clinicaltrials.gov/study/NCT07223047",
"title": "A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of BMS-986523 As Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies",
"has_exemption": false,
"start_date": "2025-11-25",
"completion_date": "2028-10-13",
"has_results": false,
"results_due": false,
"sponsor_name": "Bristol-Myers Squibb",
"sponsor_slug": "bristol-myers-squibb",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06072781",
"publication_url": "https://clinicaltrials.gov/study/NCT06072781",
"title": "A Phase 3, Randomized, Open-Label Study of Combination Therapy With Avutometinib Plus Defactinib Versus Investigator's Choice of Treatment in Patients With Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP 301)",
"has_exemption": false,
"start_date": "2024-03-18",
"completion_date": "2028-10-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Verastem, Inc.",
"sponsor_slug": "verastem-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06815003",
"publication_url": "https://clinicaltrials.gov/study/NCT06815003",
"title": "Phase-2 Study of Vedolizumab Plus Post-Transplant Cyclophosphamide and Short Course Tacrolimus for Graft-versus-Host Disease Prevention After Reduced Intensity Conditioning Peripheral Blood Stem Cell Allogeneic Hematopoietic Cell Transplantation",
"has_exemption": false,
"start_date": "2025-04-18",
"completion_date": "2028-10-15",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06796998",
"publication_url": "https://clinicaltrials.gov/study/NCT06796998",
"title": "Phase 2 Trial of Epcoritamab in Patients With Newly Diagnosed Marginal Zone Lymphoma (MZL)",
"has_exemption": false,
"start_date": "2025-10-13",
"completion_date": "2028-10-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Izidore Lossos, MD",
"sponsor_slug": "izidore-lossos-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06476704",
"publication_url": "https://clinicaltrials.gov/study/NCT06476704",
"title": "Phase 2 Study of Preoperative RAdiation Therapy With Concomitant Liposomal Transcrocetin (L-TC) in Soft tISsue Sarcomas",
"has_exemption": false,
"start_date": "2026-07-01",
"completion_date": "2028-10-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Centre Paul Strauss",
"sponsor_slug": "centre-paul-strauss",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04067336",
"publication_url": "https://clinicaltrials.gov/study/NCT04067336",
"title": "A Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients With Relapsed or Refractory Acute Myeloid Leukemia",
"has_exemption": false,
"start_date": "2019-09-12",
"completion_date": "2028-10-16",
"has_results": false,
"results_due": false,
"sponsor_name": "Kura Oncology, Inc.",
"sponsor_slug": "kura-oncology-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06572384",
"publication_url": "https://clinicaltrials.gov/study/NCT06572384",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Belimumab Administered Subcutaneously in Adults With Interstitial Lung Disease (ILD) Associated With Connective Tissue Disease (CTD)",
"has_exemption": false,
"start_date": "2024-09-11",
"completion_date": "2028-10-18",
"has_results": false,
"results_due": false,
"sponsor_name": "GlaxoSmithKline",
"sponsor_slug": "glaxosmithkline",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07197944",
"publication_url": "https://clinicaltrials.gov/study/NCT07197944",
"title": "A Phase 3, Double-blind, Randomized, Parallel Group, Placebo-controlled, Multicenter Trial to Confirm the Efficacy and Safety of Glepaglutide 10 mg Twice Weekly, Followed by a Long-term, Open-label Safety Evaluation in Patients With Short Bowel Syndrome-intestinal Failure (SBS-IF)",
"has_exemption": false,
"start_date": "2026-02-11",
"completion_date": "2028-10-23",
"has_results": false,
"results_due": false,
"sponsor_name": "Zealand Pharma",
"sponsor_slug": "zealand-pharma",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07037004",
"publication_url": "https://clinicaltrials.gov/study/NCT07037004",
"title": "Impact of Microbiome Modulation With CBM588 in Combination With Pembrolizumab for Adjuvant Therapy of High-Risk, Resected Renal Cell Carcinoma (RCC)",
"has_exemption": false,
"start_date": "2027-01-01",
"completion_date": "2028-10-24",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06818643",
"publication_url": "https://clinicaltrials.gov/study/NCT06818643",
"title": "A Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2025-03-25",
"completion_date": "2028-10-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07109414",
"publication_url": "https://clinicaltrials.gov/study/NCT07109414",
"title": "Randomized Phase 2/3 Trial of NP-G2-044 (Prilukae) Combined With PLD for Treatment of Platinum-Resistant Ovarian Cancer (ULTIMUS-1)",
"has_exemption": false,
"start_date": "2025-12-29",
"completion_date": "2028-10-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Novita Pharmaceuticals, Inc.",
"sponsor_slug": "novita-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07533942",
"publication_url": "https://clinicaltrials.gov/study/NCT07533942",
"title": "A Phase 2 Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP3507 (ONC206) in Adults With Recurrent Grade 2 or 3 Meningioma",
"has_exemption": false,
"start_date": "2026-06-01",
"completion_date": "2028-10-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Jazz Pharmaceuticals",
"sponsor_slug": "jazz-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02407028",
"publication_url": "https://clinicaltrials.gov/study/NCT02407028",
"title": "Hyperbaric Oxygen Brain Injury Treatment (HOBIT) Trial",
"has_exemption": false,
"start_date": "2018-06-25",
"completion_date": "2028-10-26",
"has_results": false,
"results_due": false,
"sponsor_name": "Gaylan Rockswold",
"sponsor_slug": "gaylan-rockswold",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05755386",
"publication_url": "https://clinicaltrials.gov/study/NCT05755386",
"title": "A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Iptacopan (LNP023) in Idiopathic Immune-complex-mediated Membranoproliferative Glomerulonephritis (IC-MPGN)",
"has_exemption": false,
"start_date": "2023-10-02",
"completion_date": "2028-10-27",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07461948",
"publication_url": "https://clinicaltrials.gov/study/NCT07461948",
"title": "Advanced MRI for Visualization and Quantification of the Tumor Immune Microenvironment (TIME) in Glioblastoma",
"has_exemption": false,
"start_date": "2025-10-27",
"completion_date": "2028-10-27",
"has_results": false,
"results_due": false,
"sponsor_name": "Jonsson Comprehensive Cancer Center",
"sponsor_slug": "jonsson-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07593391",
"publication_url": "https://clinicaltrials.gov/study/NCT07593391",
"title": "A Phase 3 Open-label Extension Study to Investigate the Long-term Safety and Efficacy of Orally Administered NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome",
"has_exemption": false,
"start_date": "2026-05-20",
"completion_date": "2028-10-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Neuren Pharmaceuticals Limited",
"sponsor_slug": "neuren-pharmaceuticals-limited",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05451849",
"publication_url": "https://clinicaltrials.gov/study/NCT05451849",
"title": "A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer",
"has_exemption": false,
"start_date": "2022-06-21",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "TCR2 Therapeutics",
"sponsor_slug": "tcr2-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06430801",
"publication_url": "https://clinicaltrials.gov/study/NCT06430801",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Moderately to Severely Active Crohn's Disease",
"has_exemption": false,
"start_date": "2024-06-05",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06678659",
"publication_url": "https://clinicaltrials.gov/study/NCT06678659",
"title": "A Phase 1 / 2, Open-Label Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer",
"has_exemption": false,
"start_date": "2024-11-21",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Recursion Pharmaceuticals Inc.",
"sponsor_slug": "recursion-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05952453",
"publication_url": "https://clinicaltrials.gov/study/NCT05952453",
"title": "A Phase II Study in Newly Diagnosed Stage III/IV Epithelial Ovarian Cancer Evaluating Carbo/Taxol/Pembro in Patients Receiving Neoadjuvant Chemotherapy (NACT) Followed by Olaparib/Pembro Maintenance",
"has_exemption": false,
"start_date": "2025-02-17",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06385262",
"publication_url": "https://clinicaltrials.gov/study/NCT06385262",
"title": "Safety, Efficacy, and Tumor Immune Microenvironment Changes With Neoadjuvant Chemotherapy and Cemiplimab With or Without Alirocumab in Stage 1B-3A Non-Small Cell Lung Cancer: TOP 2301",
"has_exemption": false,
"start_date": "2025-03-17",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Duke University",
"sponsor_slug": "duke-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06787612",
"publication_url": "https://clinicaltrials.gov/study/NCT06787612",
"title": "Multi-Arm Phase 2 Platform Study of Ubamatamab (REGN4018; MUC16×CD3 Bispecific Antibody) With or Without Additional Agents in Platinum-Resistant Ovarian Cancer",
"has_exemption": false,
"start_date": "2025-05-28",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Regeneron Pharmaceuticals",
"sponsor_slug": "regeneron-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06976619",
"publication_url": "https://clinicaltrials.gov/study/NCT06976619",
"title": "The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People",
"has_exemption": false,
"start_date": "2025-10-03",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07213817",
"publication_url": "https://clinicaltrials.gov/study/NCT07213817",
"title": "An Open-Label, Phase I/II First-in-Human, Dose Escalation, Dose Optimisation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 as Single Agent in Adult Participants With Locally Advanced or Metastatic Solid Tumours.",
"has_exemption": false,
"start_date": "2025-12-05",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Ipsen",
"sponsor_slug": "ipsen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07308834",
"publication_url": "https://clinicaltrials.gov/study/NCT07308834",
"title": "Phase 1/2a Study to Evaluate the Safety and Tolerability Intra-articular CX-011 to Treat Moderate to Severe Pain From Knee Osteoarthritis",
"has_exemption": false,
"start_date": "2026-02-01",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "CarthroniX, Inc.",
"sponsor_slug": "carthronix-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07586774",
"publication_url": "https://clinicaltrials.gov/study/NCT07586774",
"title": "An Open, Single-center, Prospective, Randomized, Two-armed, Interventional, Post-market Clinical Investigation of 3D Printed Complete Dentures and Milled Complete Dentures During a 5-year Follow-up Period",
"has_exemption": false,
"start_date": "2026-05-30",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Dentsply Sirona Implants and Consumables",
"sponsor_slug": "dentsply-sirona-implants-and-consumables",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06065670",
"publication_url": "https://clinicaltrials.gov/study/NCT06065670",
"title": "A Randomized, Double-Blind, Delayed Treatment, Placebo-Controlled Trial to Assess the Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy",
"has_exemption": false,
"start_date": "2026-09-15",
"completion_date": "2028-10-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Francisco",
"sponsor_slug": "university-of-california-san-francisco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT01269853",
"publication_url": "https://clinicaltrials.gov/study/NCT01269853",
"title": "Phase I/II Trial Of Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab (Avastin) for Treatment of Relapsed/Refractory Glioblastoma Multiforme and Anaplastic Astrocytoma.",
"has_exemption": false,
"start_date": "2010-10-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Northwell Health",
"sponsor_slug": "northwell-health",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT03219359",
"publication_url": "https://clinicaltrials.gov/study/NCT03219359",
"title": "Maintenance in Autologous Stem Cell Transplant for Crohn's Disease (MASCT - CD)",
"has_exemption": false,
"start_date": "2018-02-22",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Aaron Etra",
"sponsor_slug": "aaron-etra",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03503331",
"publication_url": "https://clinicaltrials.gov/study/NCT03503331",
"title": "UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy",
"has_exemption": false,
"start_date": "2018-04-20",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03614949",
"publication_url": "https://clinicaltrials.gov/study/NCT03614949",
"title": "Phase II Study of Stereotactic Body Radiation Therapy and Atezolizumab in the Management of Recurrent, Persistent, or Metastatic Cervical Cancer",
"has_exemption": false,
"start_date": "2019-01-29",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "H. Lee Moffitt Cancer Center and Research Institute",
"sponsor_slug": "h-lee-moffitt-cancer-center-and-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03833154",
"publication_url": "https://clinicaltrials.gov/study/NCT03833154",
"title": "A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab With Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515) Osimertinib Following SBRT, a Single Arm Cohort for Patients With Unresected Stage I/II, Lymph Node Negative NSCLC Harboring a Sensitizing EGFR Mutation",
"has_exemption": false,
"start_date": "2019-03-06",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03821129",
"publication_url": "https://clinicaltrials.gov/study/NCT03821129",
"title": "GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study",
"has_exemption": false,
"start_date": "2019-07-25",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "W.L.Gore & Associates",
"sponsor_slug": "wlgore-associates",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04133675",
"publication_url": "https://clinicaltrials.gov/study/NCT04133675",
"title": "A Single-Blind, Randomized Study of the BTL EmsellaTM Chair Versus Sham for the Treatment of Stress Urinary Incontinence",
"has_exemption": false,
"start_date": "2019-12-18",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Corewell Health East",
"sponsor_slug": "corewell-health-east",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04230109",
"publication_url": "https://clinicaltrials.gov/study/NCT04230109",
"title": "A Phase 2 Study of Response-guided Neoadjuvant Sacituzumab Govitecan (IMMU-132) in Patients With Localized Triple-Negative Breast Cancer (NeoSTAR)",
"has_exemption": false,
"start_date": "2020-07-14",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04613596",
"publication_url": "https://clinicaltrials.gov/study/NCT04613596",
"title": "A Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation",
"has_exemption": false,
"start_date": "2020-12-02",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mirati Therapeutics Inc.",
"sponsor_slug": "mirati-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04411823",
"publication_url": "https://clinicaltrials.gov/study/NCT04411823",
"title": "Prediction of Post-laparoscopic Sleeve Gastrectomy Gastroesophageal Reflux Disease With an Endolumenal Functional Lumen Imaging Probe (EndoFLIP)",
"has_exemption": false,
"start_date": "2021-02-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06342960",
"publication_url": "https://clinicaltrials.gov/study/NCT06342960",
"title": "KYSA-3: A Phase 1/2, Open-Label, Multicenter Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis",
"has_exemption": false,
"start_date": "2022-12-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Kyverna Therapeutics",
"sponsor_slug": "kyverna-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05259904",
"publication_url": "https://clinicaltrials.gov/study/NCT05259904",
"title": "Study to Improve dEployment Related Asthma by Using L-citrulline Supplementation (SEALS)",
"has_exemption": false,
"start_date": "2023-03-08",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Colorado, Denver",
"sponsor_slug": "university-of-colorado-denver",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05532943",
"publication_url": "https://clinicaltrials.gov/study/NCT05532943",
"title": "A Seamless Phase I/IIa Clinical Study to Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis",
"has_exemption": false,
"start_date": "2023-09-08",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Ever Supreme Bio Technology Co., Ltd.",
"sponsor_slug": "ever-supreme-bio-technology-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05977998",
"publication_url": "https://clinicaltrials.gov/study/NCT05977998",
"title": "A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology",
"has_exemption": false,
"start_date": "2023-09-08",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05821959",
"publication_url": "https://clinicaltrials.gov/study/NCT05821959",
"title": "A Trial of AAVAnc80-hOTOF Gene Therapy in Individuals With Sensorineural Hearing Loss Due to Otoferlin Gene Mutations",
"has_exemption": false,
"start_date": "2023-09-15",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Akouos, Inc.",
"sponsor_slug": "akouos-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06076304",
"publication_url": "https://clinicaltrials.gov/study/NCT06076304",
"title": "Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis",
"has_exemption": false,
"start_date": "2023-11-21",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Daniel Merenstein",
"sponsor_slug": "daniel-merenstein",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05951959",
"publication_url": "https://clinicaltrials.gov/study/NCT05951959",
"title": "A Multicentre, Phase II, Open-label Study to Evaluate the Efficacy of Acalabrutinib in Combination With Venetoclax and Rituximab in Participants With Treatment Naïve Mantle Cell Lymphoma (TrAVeRse)",
"has_exemption": false,
"start_date": "2023-12-13",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06140537",
"publication_url": "https://clinicaltrials.gov/study/NCT06140537",
"title": "Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients",
"has_exemption": false,
"start_date": "2024-02-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Colorado, Denver",
"sponsor_slug": "university-of-colorado-denver",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05916235",
"publication_url": "https://clinicaltrials.gov/study/NCT05916235",
"title": "Photobiomodulation for Management of Temporomandibular Disorder Pain",
"has_exemption": false,
"start_date": "2024-02-08",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Florida",
"sponsor_slug": "university-of-florida",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06572683",
"publication_url": "https://clinicaltrials.gov/study/NCT06572683",
"title": "Resonant Frequency rTMS: A Novel Approach to Target Circuit Modulation in Major Depressive Disorder",
"has_exemption": false,
"start_date": "2024-02-12",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, Los Angeles",
"sponsor_slug": "university-of-california-los-angeles",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06044623",
"publication_url": "https://clinicaltrials.gov/study/NCT06044623",
"title": "Implementing Geriatric Assessment for Dose Optimization of CDK 4/6-inhibitors in Older Breast Cancer Patients - a Pragmatic Randomized-controlled Trial (IMPORTANT Trial)",
"has_exemption": false,
"start_date": "2024-04-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Region Örebro County",
"sponsor_slug": "region-orebro-county",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06590857",
"publication_url": "https://clinicaltrials.gov/study/NCT06590857",
"title": "Phase 1b/2 Open-label Trial of 225Ac-DOTATATE (RYZ101) in Subjects With Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)-Negative, Locally Advanced and Unresectable or Metastatic Breast Cancer Expressing Somatostatin Receptors (SSTRs) and Progressed After Antibody-drug Conjugates and/or Chemotherapy (TRACY-1).",
"has_exemption": false,
"start_date": "2024-07-19",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "RayzeBio, Inc.",
"sponsor_slug": "rayzebio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06216301",
"publication_url": "https://clinicaltrials.gov/study/NCT06216301",
"title": "LUNAR-2: Pivotal, Randomized, Open-Label Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Pembrolizumab and Platinum-based Chemotherapy for the Treatment of Metastatic Non-Small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2024-07-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "NovoCure GmbH",
"sponsor_slug": "novocure-gmbh",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06506422",
"publication_url": "https://clinicaltrials.gov/study/NCT06506422",
"title": "SGLT2 Inhibition as a Therapeutic Strategy to Reverse Arterial Stiffening in Aging",
"has_exemption": false,
"start_date": "2024-08-18",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Missouri-Columbia",
"sponsor_slug": "university-of-missouri-columbia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06806930",
"publication_url": "https://clinicaltrials.gov/study/NCT06806930",
"title": "Predicting Response to Neoadjuvant Endocrine Therapy (Neo-PREDICT)",
"has_exemption": false,
"start_date": "2024-10-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "George Washington University",
"sponsor_slug": "george-washington-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05903131",
"publication_url": "https://clinicaltrials.gov/study/NCT05903131",
"title": "UPLifT-Endo: Uterine Preservation Via Lifestyle Transformation A Behavioral Intervention to Promote Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Atypical Endometrial Hyperplasia or Grade 1 Endometrial Cancer",
"has_exemption": false,
"start_date": "2024-10-24",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06733935",
"publication_url": "https://clinicaltrials.gov/study/NCT06733935",
"title": "A Phase 1/2 Study of NKX019, a CD19 Chimeric Antigen Receptor Natural Killer (CAR NK) Cell Therapy, in Subjects With Immune-Mediated Diseases",
"has_exemption": false,
"start_date": "2024-11-04",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Nkarta, Inc.",
"sponsor_slug": "nkarta-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06825689",
"publication_url": "https://clinicaltrials.gov/study/NCT06825689",
"title": "Unidos Contra el VPH: Screening Preference and Uptake of HPV Self-sampling Among Latinxs Along the US-Mexico Border",
"has_exemption": false,
"start_date": "2025-01-28",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas at Austin",
"sponsor_slug": "university-of-texas-at-austin",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06942572",
"publication_url": "https://clinicaltrials.gov/study/NCT06942572",
"title": "A Phase 1/2, First-in-Human, Open-label, Assessor-Masked, Randomized, Controlled, Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ATP Binding Cassette Subfamily A Member 4 (ABCA4) Gene",
"has_exemption": false,
"start_date": "2025-02-11",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Splice Bio",
"sponsor_slug": "splice-bio",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06841055",
"publication_url": "https://clinicaltrials.gov/study/NCT06841055",
"title": "A Phase II, Multisite, Open-label Trial of Pumitamig (BNT327) in Combination With Standard-of-care Chemotherapy in First-line and Second-line Non-small Cell Lung Cancer (NSCLC)",
"has_exemption": false,
"start_date": "2025-03-03",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Biontech SE",
"sponsor_slug": "biontech-se",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06817668",
"publication_url": "https://clinicaltrials.gov/study/NCT06817668",
"title": "Evaluating Tolerability of Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT) With High Dose Rate Brachytherapy Boost for Unfavorable and Higher Risk Prostate Cancer",
"has_exemption": false,
"start_date": "2025-03-05",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Indiana University",
"sponsor_slug": "indiana-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06533865",
"publication_url": "https://clinicaltrials.gov/study/NCT06533865",
"title": "Romosozumab as an Adjunct to Physiologic Estrogen Replacement in Adolescents and Young Adults With Functional Hypothalamic Amenorrhea",
"has_exemption": false,
"start_date": "2025-03-19",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06635811",
"publication_url": "https://clinicaltrials.gov/study/NCT06635811",
"title": "Circadian Adaptive Deep Brain Stimulation in Essential Tremor",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Florida",
"sponsor_slug": "university-of-florida",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06960577",
"publication_url": "https://clinicaltrials.gov/study/NCT06960577",
"title": "A Phase IIIb, Open-label, Single-arm, Global Study of Perioperative Durvalumab With Neoadjuvant ddMVAC or Gem/Cis in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)",
"has_exemption": false,
"start_date": "2025-05-15",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06680752",
"publication_url": "https://clinicaltrials.gov/study/NCT06680752",
"title": "A Phase 1/2, Open-label, Multicenter Trial to Assess the Safety and Efficacy of ARD103 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome",
"has_exemption": false,
"start_date": "2025-05-20",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "ARCE Therapeutics, Inc.",
"sponsor_slug": "arce-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06693011",
"publication_url": "https://clinicaltrials.gov/study/NCT06693011",
"title": "Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial",
"has_exemption": false,
"start_date": "2025-06-10",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Cerus Endovascular, Inc.",
"sponsor_slug": "cerus-endovascular-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06328608",
"publication_url": "https://clinicaltrials.gov/study/NCT06328608",
"title": "Multi-centre, Open-label Trial to Assess the saFety, Pharmacodynamics, Efficacy and Pharmacokinetics of pegunigaLsidase Alfa in Patients From 2 Years to Less Than 18 Years of Age With Confirmed FabrY Disease",
"has_exemption": false,
"start_date": "2025-07-29",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Chiesi Farmaceutici S.p.A.",
"sponsor_slug": "chiesi-farmaceutici-spa",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06854159",
"publication_url": "https://clinicaltrials.gov/study/NCT06854159",
"title": "A Phase 2 Study of Odronextamab in Relapsed/ Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL) Before and After Chimeric Antigen Receptor (CAR) T-Cell Therapy",
"has_exemption": false,
"start_date": "2025-08-07",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, Davis",
"sponsor_slug": "university-of-california-davis",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07416149",
"publication_url": "https://clinicaltrials.gov/study/NCT07416149",
"title": "Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence (NIRAF)- Assisted Total Thyroidectomy Versus Conventional Total Thyroidectomy, a Randomized-controlled Trial",
"has_exemption": false,
"start_date": "2025-09-16",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "The University of Hong Kong",
"sponsor_slug": "the-university-of-hong-kong",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07224256",
"publication_url": "https://clinicaltrials.gov/study/NCT07224256",
"title": "VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration",
"has_exemption": false,
"start_date": "2025-10-03",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Neuralink Corp",
"sponsor_slug": "neuralink-corp",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06330493",
"publication_url": "https://clinicaltrials.gov/study/NCT06330493",
"title": "Prospective Multi-Center Randomized Controlled Trial to Evaluate the Safety and Efficacy of AcoArt Litos Paclitaxel Coated Percutaneous Transluminal Angioplasty (PTA) Balloon Versus Non-Coated Standard Balloon Angioplasty for the Treatment of Infrapopliteal Obstructions in Patients With Chronic Limb-Threatening Ischemia",
"has_exemption": false,
"start_date": "2025-10-10",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Acotec Scientific Co., Ltd",
"sponsor_slug": "acotec-scientific-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06784336",
"publication_url": "https://clinicaltrials.gov/study/NCT06784336",
"title": "Phase II Multi-center Study of Resistant Potato Starch Plus Deferasirox to Improve Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation",
"has_exemption": false,
"start_date": "2025-10-15",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Michigan Rogel Cancer Center",
"sponsor_slug": "university-of-michigan-rogel-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07115004",
"publication_url": "https://clinicaltrials.gov/study/NCT07115004",
"title": "A Prospective, Multicenter, Open-label, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of Prophylactic VGA039 in Adolescent and Adult Patients With Von Willebrand Disease (VIVID-6)",
"has_exemption": false,
"start_date": "2025-10-15",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Vega Therapeutics, Inc",
"sponsor_slug": "vega-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07045194",
"publication_url": "https://clinicaltrials.gov/study/NCT07045194",
"title": "A Prospective, Multi-center, Single-blind, Randomized (1:1), Non-inferiority Study Comparing Clinical Outcomes of the Virtue® Sirolimus AngioInfusion™ Balloon (SAB) to the AGENT™ Paclitaxel Drug-Coated Balloon (DCB) in the Treatment of Coronary Artery In-stent Restenosis (ISR).",
"has_exemption": false,
"start_date": "2025-10-20",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Orchestra BioMed, Inc",
"sponsor_slug": "orchestra-biomed-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07194850",
"publication_url": "https://clinicaltrials.gov/study/NCT07194850",
"title": "A Multicenter, Randomized, Double-blinded, Parallel-Arm, Placebo-Controlled, Pharmacokinetic and Pharmacodynamic Study Followed by an Open-Label Arm to Evaluate Efgartigimod IV in Pediatric Participants From 12 Years to Less Than 18 Years of Age With Chronic ITP",
"has_exemption": false,
"start_date": "2025-10-20",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "argenx",
"sponsor_slug": "argenx",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07223021",
"publication_url": "https://clinicaltrials.gov/study/NCT07223021",
"title": "Improving EveNt Free Survival by Optimizing FLUdarabine Exposure During LymphodepletioN for CAR T CEll Therapy: a Randomized, Multi-center Study of Children and Young Adults With B-cell Acute Lymphoblastic Leukemia (INFLUENCE)",
"has_exemption": false,
"start_date": "2025-10-20",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06878560",
"publication_url": "https://clinicaltrials.gov/study/NCT06878560",
"title": "EXPAND: A Prospective Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With End-stage Renal Disease (ESRD)",
"has_exemption": false,
"start_date": "2025-10-29",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "United Therapeutics",
"sponsor_slug": "united-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07225751",
"publication_url": "https://clinicaltrials.gov/study/NCT07225751",
"title": "A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions",
"has_exemption": false,
"start_date": "2025-11-25",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Kuros Biosurgery AG",
"sponsor_slug": "kuros-biosurgery-ag",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07357415",
"publication_url": "https://clinicaltrials.gov/study/NCT07357415",
"title": "A Phase 3b Study to Investigate the Efficacy and Safety of Different Retatrutide Dose Escalation Schemes in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Controlled, Double-Blind Trial",
"has_exemption": false,
"start_date": "2026-01-24",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Eli Lilly and Company",
"sponsor_slug": "eli-lilly-and-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07389590",
"publication_url": "https://clinicaltrials.gov/study/NCT07389590",
"title": "A Pilot Study of Ublituximab in People With MS Experiencing Wearing Off Phenomena While Receiving Treatment With Ocrelizumab",
"has_exemption": false,
"start_date": "2026-02-10",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Johns Hopkins University",
"sponsor_slug": "johns-hopkins-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06510309",
"publication_url": "https://clinicaltrials.gov/study/NCT06510309",
"title": "A Phase II Study Using Rituximab Plus Venetoclax in the Front Line Treatment of Marginal Zone Lymphoma",
"has_exemption": false,
"start_date": "2026-02-11",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Gottfried von Keudell, MD PhD",
"sponsor_slug": "gottfried-von-keudell-md-phd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07368998",
"publication_url": "https://clinicaltrials.gov/study/NCT07368998",
"title": "A Phase II, Randomized, Open-Label Study Evaluating Two Inavolisib Dose Levels in Combination With Fulvestrant in Participants With PIK3CA-Mutated, HR-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer",
"has_exemption": false,
"start_date": "2026-02-18",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07291297",
"publication_url": "https://clinicaltrials.gov/study/NCT07291297",
"title": "Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma",
"has_exemption": false,
"start_date": "2026-03-04",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Wake Forest University Health Sciences",
"sponsor_slug": "wake-forest-university-health-sciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07062354",
"publication_url": "https://clinicaltrials.gov/study/NCT07062354",
"title": "A Phase II Study of Combined Amivantamab, Carboplatin and Paclitaxel in Unresectable Locally Recurrent or Metastatic Head and Neck Cancer",
"has_exemption": false,
"start_date": "2026-03-25",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "SWOG Cancer Research Network",
"sponsor_slug": "swog-cancer-research-network",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07225270",
"publication_url": "https://clinicaltrials.gov/study/NCT07225270",
"title": "A Randomized, Open-Label, Phase 3 Study of Rinatabart Sesutecan (Rina-S) Plus Standard of Care Versus Standard of Care as Maintenance Treatment After 2L Platinum-Based Doublet Chemotherapy in Participants With Recurrent Platinum-Sensitive Ovarian Cancer (PSOC)",
"has_exemption": false,
"start_date": "2026-04-03",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Genmab",
"sponsor_slug": "genmab",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06891885",
"publication_url": "https://clinicaltrials.gov/study/NCT06891885",
"title": "A Prospective, Open-label, Single-arm, Dose-escalation Study of the Safety and Tolerability of a Single Subretinal Uniocular Injection of Allogeneic Induced Pluripotent Stem Cell (iPSC)-Derived Retinal Sheets (DSP-3077) in Adults With Retinitis Pigmentosa (RP)",
"has_exemption": false,
"start_date": "2026-04-16",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Sumitomo Pharma America, Inc.",
"sponsor_slug": "sumitomo-pharma-america-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07602036",
"publication_url": "https://clinicaltrials.gov/study/NCT07602036",
"title": "Type 2 Diabetes and Pregnancy a Single-arm Interventional Study",
"has_exemption": false,
"start_date": "2026-05-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Poznan University of Medical Sciences",
"sponsor_slug": "poznan-university-of-medical-sciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07555938",
"publication_url": "https://clinicaltrials.gov/study/NCT07555938",
"title": "A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Patients With Multiple Myeloma Who Have Received One to Three Prior Lines of Therapy",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07619482",
"publication_url": "https://clinicaltrials.gov/study/NCT07619482",
"title": "A Phase 1/2 Dose Escalation Followed by a Masked, Randomized, Placebo-Controlled Study to Evaluate Topical Insulin for Neuroprotection in Open Angle Glaucoma",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06205589",
"publication_url": "https://clinicaltrials.gov/study/NCT06205589",
"title": "A Phase 2a/2b Study Evaluating Safety, Immunogenicity, and Therapeutic Efficacy of ID93 + GLA-SE Vaccination in Participants With Rifampicin-Susceptible Pulmonary TB",
"has_exemption": false,
"start_date": "2026-07-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections",
"sponsor_slug": "advancing-clinical-therapeutics-globally-for-hivaids-and-other-infections",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05882344",
"publication_url": "https://clinicaltrials.gov/study/NCT05882344",
"title": "Cholinergic Deep Brain Stimulation for Alzheimer's Disease",
"has_exemption": false,
"start_date": "2026-07-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Vanderbilt University Medical Center",
"sponsor_slug": "vanderbilt-university-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07290777",
"publication_url": "https://clinicaltrials.gov/study/NCT07290777",
"title": "A Phase 2, Randomized, Partially Blinded, Controlled, Dose-ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of VEL-101 in Kidney Transplant Recipients.",
"has_exemption": false,
"start_date": "2026-07-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Veloxis Pharmaceuticals",
"sponsor_slug": "veloxis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07680439",
"publication_url": "https://clinicaltrials.gov/study/NCT07680439",
"title": "A Phase 2 Pivotal Study of BCB-276, a B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma",
"has_exemption": false,
"start_date": "2026-07-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "BrainChild Bio, Inc",
"sponsor_slug": "brainchild-bio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07135687",
"publication_url": "https://clinicaltrials.gov/study/NCT07135687",
"title": "Oral Losartan to Decrease the Risk of Postoperative Arthrofibrosis Following Primary and Revision Anterior Cruciate Ligament Reconstruction",
"has_exemption": false,
"start_date": "2026-08-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Rush University Medical Center",
"sponsor_slug": "rush-university-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07566364",
"publication_url": "https://clinicaltrials.gov/study/NCT07566364",
"title": "A Phase 2 Study Of Mosunetuzumab In Patients With Chronic Lymphocytic Leukemia With Positive Measurable Residual Disease",
"has_exemption": false,
"start_date": "2026-10-01",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06272201",
"publication_url": "https://clinicaltrials.gov/study/NCT06272201",
"title": "Incisionless Suture Plications in a POSE2.0 Interventional Randomized Obesity Study (The INSPIRO Study)",
"has_exemption": false,
"start_date": "2026-10-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "USGI Medical",
"sponsor_slug": "usgi-medical",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06675435",
"publication_url": "https://clinicaltrials.gov/study/NCT06675435",
"title": "The Effect of Inhaled Nitric Oxide on Intrapulmonary Shunt in Acutely Hypoxemic Patients With Severe Obesity",
"has_exemption": false,
"start_date": "2026-10-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06916325",
"publication_url": "https://clinicaltrials.gov/study/NCT06916325",
"title": "DeLIVER Trial: A Prospective, Multi-Center, Single-Arm, Open Label Trial of Deceased Donor Livers Transplanted After DHOPE With eXVIVO LIVER Perfusion",
"has_exemption": false,
"start_date": "2027-01-31",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "XVIVO Perfusion",
"sponsor_slug": "xvivo-perfusion",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04266275",
"publication_url": "https://clinicaltrials.gov/study/NCT04266275",
"title": "An Investigation in the Use of Curcumin Topical Herbal Agent for the Treatment of Cervical Intraepithelial Neoplasia",
"has_exemption": false,
"start_date": "2027-04-30",
"completion_date": "2028-10-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Lisa Flowers",
"sponsor_slug": "lisa-flowers",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05517655",
"publication_url": "https://clinicaltrials.gov/study/NCT05517655",
"title": "BEGIN Novel ImagiNG Biomarkers",
"has_exemption": false,
"start_date": "2022-05-01",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Children's Hospital Medical Center, Cincinnati",
"sponsor_slug": "childrens-hospital-medical-center-cincinnati",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03934905",
"publication_url": "https://clinicaltrials.gov/study/NCT03934905",
"title": "Phase II Trial of Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction (CRI18-026)",
"has_exemption": false,
"start_date": "2022-06-01",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Texas Tech University Health Sciences Center",
"sponsor_slug": "texas-tech-university-health-sciences-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06080503",
"publication_url": "https://clinicaltrials.gov/study/NCT06080503",
"title": "G-FORCE: Phase II Randomized Study of Glottic Larynx Hypofractionated Radiotherapy Versus ConvEntional Radiotherapy",
"has_exemption": false,
"start_date": "2024-03-14",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas Southwestern Medical Center",
"sponsor_slug": "university-of-texas-southwestern-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06709495",
"publication_url": "https://clinicaltrials.gov/study/NCT06709495",
"title": "Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas",
"has_exemption": false,
"start_date": "2025-01-27",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "David S Shulman, MD",
"sponsor_slug": "david-s-shulman-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06819007",
"publication_url": "https://clinicaltrials.gov/study/NCT06819007",
"title": "A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01/ENGOT-ov89/GEICO144- O/GOG-3112/APGOT-OV13)",
"has_exemption": false,
"start_date": "2025-03-19",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Daiichi Sankyo",
"sponsor_slug": "daiichi-sankyo",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06973629",
"publication_url": "https://clinicaltrials.gov/study/NCT06973629",
"title": "A Two-Part Phase 3b Randomized, Double-Blind, Placebo-Controlled, Followed by Open-Label Extension, Multicenter Study of the Efficacy and Safety of MSC-NTF (NurOwn) in Participants With With Early Symptomatic and Moderate Disease Presentation in Amyotrophic Lateral Sclerosis (ALS)",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Brainstorm-Cell Therapeutics",
"sponsor_slug": "brainstorm-cell-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07217301",
"publication_url": "https://clinicaltrials.gov/study/NCT07217301",
"title": "A Randomized, Open Label, Multicenter, Phase 3 Trial Evaluating the Efficacy and Safety of TAK-928 Versus Docetaxel in Participants With Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Disease Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy",
"has_exemption": false,
"start_date": "2025-11-26",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Takeda",
"sponsor_slug": "takeda",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07283731",
"publication_url": "https://clinicaltrials.gov/study/NCT07283731",
"title": "Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma",
"has_exemption": false,
"start_date": "2026-06-02",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07126561",
"publication_url": "https://clinicaltrials.gov/study/NCT07126561",
"title": "Phase II Open Label Trial of Trastuzumab Deruxtecan (Enhertu, DS-8210) in HER2 Positive Newly Diagnosed Metastatic Esophageal, Gastric, GEJ Cancer Patients With an ECOG Performance Status of 2",
"has_exemption": false,
"start_date": "2026-11-01",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Chicago",
"sponsor_slug": "university-of-chicago",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07538336",
"publication_url": "https://clinicaltrials.gov/study/NCT07538336",
"title": "Targeting Interferon Gamma With Emapalumab to Lung Transplant Recipients With Interferon Gamma-high Acute Lung Allograft Dysfunction",
"has_exemption": false,
"start_date": "2026-11-02",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Francisco",
"sponsor_slug": "university-of-california-san-francisco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05931484",
"publication_url": "https://clinicaltrials.gov/study/NCT05931484",
"title": "A Phase 2, Double-Blind, Multi-Center, Placebo-Controlled Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of FHL-301 in Adult Patients With Parkinson's Disease",
"has_exemption": false,
"start_date": "2027-11-01",
"completion_date": "2028-11-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Forest Hills Lab",
"sponsor_slug": "forest-hills-lab",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06152237",
"publication_url": "https://clinicaltrials.gov/study/NCT06152237",
"title": "A Multicenter, Open Label, Randomized, Dose-Escalation and Dose-Expansion Study of the Safety, Tolerability, and Efficacy of a Single Intrathecal Administration of TSHA-102, an AAV9-Delivered Gene Therapy, for the Treatment of Pediatric Females With Rett Syndrome",
"has_exemption": false,
"start_date": "2023-12-12",
"completion_date": "2028-11-02",
"has_results": false,
"results_due": false,
"sponsor_name": "Taysha Gene Therapies, Inc.",
"sponsor_slug": "taysha-gene-therapies-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06750289",
"publication_url": "https://clinicaltrials.gov/study/NCT06750289",
"title": "BRISOTE: A Multicentre, Randomised, Double-Blind, Parallel Group, Active-Controlled, Phase 3b Study to Evaluate the Efficacy and Safety of Benralizumab 30 mg SC in Eosinophilic Asthma Patients Uncontrolled on Medium-Dose Inhaled Corticosteroid Plus Long-acting β2-Agonist.",
"has_exemption": false,
"start_date": "2025-03-28",
"completion_date": "2028-11-03",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07011745",
"publication_url": "https://clinicaltrials.gov/study/NCT07011745",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease",
"has_exemption": false,
"start_date": "2025-07-16",
"completion_date": "2028-11-03",
"has_results": false,
"results_due": false,
"sponsor_name": "Bristol-Myers Squibb",
"sponsor_slug": "bristol-myers-squibb",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06189313",
"publication_url": "https://clinicaltrials.gov/study/NCT06189313",
"title": "A Prospective, Multicenter Study to Evaluate the Safety and Efficacy of an Aspiration Thrombectomy System in Acute Pulmonary Embolism",
"has_exemption": false,
"start_date": "2025-01-03",
"completion_date": "2028-11-04",
"has_results": false,
"results_due": false,
"sponsor_name": "Argon Medical Devices",
"sponsor_slug": "argon-medical-devices",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07160244",
"publication_url": "https://clinicaltrials.gov/study/NCT07160244",
"title": "A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS",
"has_exemption": false,
"start_date": "2025-08-25",
"completion_date": "2028-11-06",
"has_results": false,
"results_due": false,
"sponsor_name": "Pfizer",
"sponsor_slug": "pfizer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06504394",
"publication_url": "https://clinicaltrials.gov/study/NCT06504394",
"title": "A Phase 2 Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) in Participants With Relapsed or Refractory Classical Hodgkin Lymphoma (rrcHL) or Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma (rrPMBCL)",
"has_exemption": false,
"start_date": "2024-10-14",
"completion_date": "2028-11-08",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04375800",
"publication_url": "https://clinicaltrials.gov/study/NCT04375800",
"title": "A Phase 2 Clinical Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Doravirine and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in Participants With HIV-1, Who Are 4 Weeks to Less Than 12 Years of Age and Weigh Less Than 45 kg",
"has_exemption": false,
"start_date": "2021-02-03",
"completion_date": "2028-11-12",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06161519",
"publication_url": "https://clinicaltrials.gov/study/NCT06161519",
"title": "Phase I/II Trial of PLX038 in Primary Central Nervous System Tumors With and Without MYC or MYCN Amplifications",
"has_exemption": false,
"start_date": "2024-01-31",
"completion_date": "2028-11-14",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07301034",
"publication_url": "https://clinicaltrials.gov/study/NCT07301034",
"title": "Effects of Ziltivekimab Versus Placebo on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction. A Serial, Multivessel, Intravascular Ultrasound, Near-infrared Spectroscopy and Optical Coherence Tomography Imaging Study",
"has_exemption": false,
"start_date": "2025-12-18",
"completion_date": "2028-11-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Novo Nordisk A/S",
"sponsor_slug": "novo-nordisk-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07335562",
"publication_url": "https://clinicaltrials.gov/study/NCT07335562",
"title": "A Phase 3, Randomized, Open-label, Multicenter Study to Compare the Efficacy and Safety of BMS-986353, CD19-targeted NEX-T CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis (Breakfree-SSc)",
"has_exemption": false,
"start_date": "2026-08-29",
"completion_date": "2028-11-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Juno Therapeutics, Inc., a Bristol-Myers Squibb Company",
"sponsor_slug": "juno-therapeutics-inc-a-bristol-myers-squibb-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04626024",
"publication_url": "https://clinicaltrials.gov/study/NCT04626024",
"title": "Safety And Efficacy Of Tyrosine Kinase Inhibitor Cessation For Chronic Myeloid Leukemia Patients With Stable Molecular Response In A Real World Population",
"has_exemption": false,
"start_date": "2020-12-22",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Baylor College of Medicine",
"sponsor_slug": "baylor-college-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05051033",
"publication_url": "https://clinicaltrials.gov/study/NCT05051033",
"title": "Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)",
"has_exemption": false,
"start_date": "2022-02-21",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Annetine Gelijns",
"sponsor_slug": "annetine-gelijns",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06144606",
"publication_url": "https://clinicaltrials.gov/study/NCT06144606",
"title": "Phase 2 Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)",
"has_exemption": false,
"start_date": "2023-12-26",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "H. Lee Moffitt Cancer Center and Research Institute",
"sponsor_slug": "h-lee-moffitt-cancer-center-and-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06571383",
"publication_url": "https://clinicaltrials.gov/study/NCT06571383",
"title": "Weight Maintenance in Adolescents With Obesity; Long-Term Treatment With Semaglutide s.c.2.4 mg Once-weekly",
"has_exemption": false,
"start_date": "2024-09-17",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Novo Nordisk A/S",
"sponsor_slug": "novo-nordisk-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06847542",
"publication_url": "https://clinicaltrials.gov/study/NCT06847542",
"title": "A Phase IIIb, Multicenter, Single-arm Study Assessing the Effectiveness, Safety and Patient Reported Outcomes of a 36-week Refill Exchange Regimen for the Port Delivery System With Ranibizumab in Patients With Neovascular Age-related Macular Degeneration",
"has_exemption": false,
"start_date": "2025-11-27",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07092527",
"publication_url": "https://clinicaltrials.gov/study/NCT07092527",
"title": "Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version",
"has_exemption": false,
"start_date": "2025-12-05",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Diego",
"sponsor_slug": "university-of-california-san-diego",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07214779",
"publication_url": "https://clinicaltrials.gov/study/NCT07214779",
"title": "A Phase 3, Randomized, Open-Label Study of INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression",
"has_exemption": false,
"start_date": "2025-12-09",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Incyte Corporation",
"sponsor_slug": "incyte-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05490277",
"publication_url": "https://clinicaltrials.gov/study/NCT05490277",
"title": "Vibrotactile Coordinated Reset for the Treatment of Chronic Stroke",
"has_exemption": false,
"start_date": "2026-01-15",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07411599",
"publication_url": "https://clinicaltrials.gov/study/NCT07411599",
"title": "Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial (\"Chip-CRC Trial\")",
"has_exemption": false,
"start_date": "2026-04-20",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07499232",
"publication_url": "https://clinicaltrials.gov/study/NCT07499232",
"title": "A Phase 3b, Multicenter, Randomized, Open-Label, Active-Controlled Study to Compare the Efficacy and Safety of Guselkumab Versus Risankizumab in the Treatment of Participants With Moderately to Severely Active Crohn's Disease",
"has_exemption": false,
"start_date": "2026-04-21",
"completion_date": "2028-11-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06097728",
"publication_url": "https://clinicaltrials.gov/study/NCT06097728",
"title": "A Phase III, Randomized, Open-Label, Multicenter, Global Study of Volrustomig (MEDI5752) in Combination With Carboplatin Plus Pemetrexed Versus Platinum Plus Pemetrexed or Nivolumab Plus Ipilimumab in Participants With Unresectable Pleural Mesothelioma (eVOLVE-Meso)",
"has_exemption": false,
"start_date": "2023-11-09",
"completion_date": "2028-11-16",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07218809",
"publication_url": "https://clinicaltrials.gov/study/NCT07218809",
"title": "A Randomised, Open-label, Phase III Study of AZD5335 Versus Mirvetuximab Soravtansine in FRα-high and AZD5335 Versus Investigator's Choice Chemotherapy in FRα-low Expressing High-grade Platinum-resistant Epithelial Ovarian Cancer Patients (TREVI-OC-01)",
"has_exemption": false,
"start_date": "2025-12-29",
"completion_date": "2028-11-17",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06858735",
"publication_url": "https://clinicaltrials.gov/study/NCT06858735",
"title": "HYPERION CCA: a Phase 2 Trial of Systemic Therapy With or Without Liver-directed Radiation Therapy for Patients With Advanced Intrahepatic Cholangiocarcinoma",
"has_exemption": false,
"start_date": "2025-06-10",
"completion_date": "2028-11-19",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07252050",
"publication_url": "https://clinicaltrials.gov/study/NCT07252050",
"title": "Ruxolitinib-Enhanced Conditioning for Pediatric and Young Adult Patients With Symptomatic Sickle Cell Disease Undergoing Haploidentical Hematopoietic Cell Transplantation",
"has_exemption": false,
"start_date": "2026-06-08",
"completion_date": "2028-11-19",
"has_results": false,
"results_due": false,
"sponsor_name": "Arkansas Children's Hospital Research Institute",
"sponsor_slug": "arkansas-childrens-hospital-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06112379",
"publication_url": "https://clinicaltrials.gov/study/NCT06112379",
"title": "A Phase III, Open-label, Randomised Study of Neoadjuvant Datopotamab Deruxtecan (Dato-DXd) Plus Durvalumab Followed by Adjuvant Durvalumab With or Without Chemotherapy Versus Neoadjuvant Pembrolizumab Plus Chemotherapy Followed by Adjuvant Pembrolizumab With or Without Chemotherapy for the Treatment of Adult Patients With Previously Untreated Triple-Negative or Hormone Receptor-low/HER2-negative Breast Cancer (D926QC00001; TROPION-Breast04)",
"has_exemption": false,
"start_date": "2023-11-14",
"completion_date": "2028-11-20",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07430592",
"publication_url": "https://clinicaltrials.gov/study/NCT07430592",
"title": "A Phase 2B Trial of the Combination of SJ733 and Tafenoquine for Radical Cure of P. Vivax Malaria in Comparison to Chloroquine-Tafenoquine",
"has_exemption": false,
"start_date": "2026-07-01",
"completion_date": "2028-11-20",
"has_results": false,
"results_due": false,
"sponsor_name": "R. Kiplin Guy",
"sponsor_slug": "r-kiplin-guy",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07011732",
"publication_url": "https://clinicaltrials.gov/study/NCT07011732",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease",
"has_exemption": false,
"start_date": "2025-07-10",
"completion_date": "2028-11-24",
"has_results": false,
"results_due": false,
"sponsor_name": "Bristol-Myers Squibb",
"sponsor_slug": "bristol-myers-squibb",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07257055",
"publication_url": "https://clinicaltrials.gov/study/NCT07257055",
"title": "Phase 2 Study of BTKi-Rituximab Induction Followed by Glofitamab Consolidation in High Risk Untreated MCL Patients - WINDOW-4 Study",
"has_exemption": false,
"start_date": "2026-04-01",
"completion_date": "2028-11-24",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03686657",
"publication_url": "https://clinicaltrials.gov/study/NCT03686657",
"title": "A 26-week Single Site, Randomized, Double-blind, Active-controlled, Parallel Group, Human PoC Study to Evaluate Superiority of RK-01, Valsartan Plus Celecoxib Addon to Metformin Versus Metformin Alone in Type 2 Diabetes Patients",
"has_exemption": false,
"start_date": "2025-10-10",
"completion_date": "2028-11-26",
"has_results": false,
"results_due": false,
"sponsor_name": "ARKAY Therapeutics",
"sponsor_slug": "arkay-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06947993",
"publication_url": "https://clinicaltrials.gov/study/NCT06947993",
"title": "A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase II Platform Study to Assess the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis",
"has_exemption": false,
"start_date": "2025-05-16",
"completion_date": "2028-11-27",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05457283",
"publication_url": "https://clinicaltrials.gov/study/NCT05457283",
"title": "An 18-month, Open-label, Single-arm Safety Extension Study of an age-and Bodyweight-adjusted Oral Finerenone Regimen, in Addition to an ACEI or ARB, for the Treatment of Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria",
"has_exemption": false,
"start_date": "2022-11-08",
"completion_date": "2028-11-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Bayer",
"sponsor_slug": "bayer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06184152",
"publication_url": "https://clinicaltrials.gov/study/NCT06184152",
"title": "Contrast Ultrasound vs. Abbreviated MRI for Detection of HCC in Patients With Indeterminate Liver Nodules",
"has_exemption": false,
"start_date": "2023-11-28",
"completion_date": "2028-11-28",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas Southwestern Medical Center",
"sponsor_slug": "university-of-texas-southwestern-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07321574",
"publication_url": "https://clinicaltrials.gov/study/NCT07321574",
"title": "An Open-Label, Multi-Cohort Phase IIb Clinical Study Evaluating the Efficacy and Safety of ABP1011T Tablets in Patients With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2025-12-30",
"completion_date": "2028-11-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Shanghai AB PharmaTech Ltd.",
"sponsor_slug": "shanghai-ab-pharmatech-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07221669",
"publication_url": "https://clinicaltrials.gov/study/NCT07221669",
"title": "An Open-Label Study to Assess the Efficacy and Safety of Multiple Doses of Salanersen (BIIB115) Delivered Intrathecally to Treatment-Naïve, Presymptomatic Infants With Genetically Diagnosed Spinal Muscular Atrophy",
"has_exemption": false,
"start_date": "2026-04-28",
"completion_date": "2028-11-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Biogen",
"sponsor_slug": "biogen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06649110",
"publication_url": "https://clinicaltrials.gov/study/NCT06649110",
"title": "A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of LTP001 in Healthy Adult Participants (Part A) and to Evaluate the Efficacy and Safety of LTP001 for the Treatment of Participants With Pulmonary Arterial Hypertension (Part B)",
"has_exemption": false,
"start_date": "2024-10-24",
"completion_date": "2028-11-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT00682318",
"publication_url": "https://clinicaltrials.gov/study/NCT00682318",
"title": "Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers: a Randomized Double-blinded Trial on the Modulation of the Eicosanoid and Isoprostane Pathways in Healthy Subjects by Omega-3 Polyunsaturated Fatty Acids and Red Wine.",
"has_exemption": false,
"start_date": "2008-05-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Carsten Skarke, MD",
"sponsor_slug": "carsten-skarke-md",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT03301506",
"publication_url": "https://clinicaltrials.gov/study/NCT03301506",
"title": "ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)",
"has_exemption": false,
"start_date": "2017-12-12",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Gilead Sciences",
"sponsor_slug": "gilead-sciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03833921",
"publication_url": "https://clinicaltrials.gov/study/NCT03833921",
"title": "Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity, PSA Decline and Genetic Variation in Proteins Involved in Androgen Metabolism in Metastatic Hormone Naive Prostate Cancer",
"has_exemption": false,
"start_date": "2019-05-23",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Martha Mims",
"sponsor_slug": "martha-mims",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04781972",
"publication_url": "https://clinicaltrials.gov/study/NCT04781972",
"title": "Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD",
"has_exemption": false,
"start_date": "2021-07-27",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Johns Hopkins University",
"sponsor_slug": "johns-hopkins-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05079841",
"publication_url": "https://clinicaltrials.gov/study/NCT05079841",
"title": "The Stimulation To Induce Mothers (STIM) Study: A Parallel Group Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2021-11-15",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05228145",
"publication_url": "https://clinicaltrials.gov/study/NCT05228145",
"title": "A Phase 1/2 Intracerebroventricular and Intravitreal Administration of NGN-101 for Treatment of Neuronal Ceroid Lipofuscinosis (NCL) Subtype 5 (CLN5) Disease",
"has_exemption": false,
"start_date": "2022-01-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Neurogene Inc.",
"sponsor_slug": "neurogene-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05076617",
"publication_url": "https://clinicaltrials.gov/study/NCT05076617",
"title": "An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures",
"has_exemption": false,
"start_date": "2022-02-03",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "UCB Biopharma SRL",
"sponsor_slug": "ucb-biopharma-srl",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05121376",
"publication_url": "https://clinicaltrials.gov/study/NCT05121376",
"title": "A Phase 1/2 Open-Label, Dose-Escalation Study to Determine the Safety Tolerability & Efficacy of BMN 331 an AAV Vector-Mediated Gene Transfer of Human SERPING1 Gene in Subjects With HAE Due to Human C1-INH Deficiency",
"has_exemption": false,
"start_date": "2022-02-15",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "BioMarin Pharmaceutical",
"sponsor_slug": "biomarin-pharmaceutical",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05281731",
"publication_url": "https://clinicaltrials.gov/study/NCT05281731",
"title": "Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma",
"has_exemption": false,
"start_date": "2022-04-18",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05194111",
"publication_url": "https://clinicaltrials.gov/study/NCT05194111",
"title": "Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan (Treat HF)",
"has_exemption": false,
"start_date": "2022-08-11",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Virginia Commonwealth University",
"sponsor_slug": "virginia-commonwealth-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05278208",
"publication_url": "https://clinicaltrials.gov/study/NCT05278208",
"title": "Phase I/II Study of Lutathera in Patients With Recurrent and/or Progressive High-Grade Central Nervous System Tumors and Meningiomas That Demonstrate Uptake on DOTATATE PET",
"has_exemption": false,
"start_date": "2022-11-21",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Nationwide Children's Hospital",
"sponsor_slug": "nationwide-childrens-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05796375",
"publication_url": "https://clinicaltrials.gov/study/NCT05796375",
"title": "Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance",
"has_exemption": false,
"start_date": "2023-11-17",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "White River Junction Veterans Affairs Medical Center",
"sponsor_slug": "white-river-junction-veterans-affairs-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06157528",
"publication_url": "https://clinicaltrials.gov/study/NCT06157528",
"title": "Diagnosis of Pelvic Endometriosis: a Preliminary Study on the Added Value of R2*MFGRE Sequence in MRI",
"has_exemption": false,
"start_date": "2023-12-20",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Zhenshen Ma",
"sponsor_slug": "zhenshen-ma",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06169852",
"publication_url": "https://clinicaltrials.gov/study/NCT06169852",
"title": "Stimulus-Evoked Directional Field Potentials to Guide Subthalamic and Pallidal DBS for PD",
"has_exemption": false,
"start_date": "2024-01-12",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06075953",
"publication_url": "https://clinicaltrials.gov/study/NCT06075953",
"title": "DCIS: RECAST Trial -Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment: a Breast Cancer Prevention Pilot Study",
"has_exemption": false,
"start_date": "2024-02-17",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "QuantumLeap Healthcare Collaborative",
"sponsor_slug": "quantumleap-healthcare-collaborative",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05940324",
"publication_url": "https://clinicaltrials.gov/study/NCT05940324",
"title": "Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)",
"has_exemption": false,
"start_date": "2024-02-24",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06316297",
"publication_url": "https://clinicaltrials.gov/study/NCT06316297",
"title": "A Phase I/II, Randomized, Placebo-controlled, Multi-arm, Dose-finding Study to Evaluate the Safety, Efficacy and Immunogenicity of an Acne mRNA Vaccine Candidate in Adults With Moderate to Severe Acne 18 to 45 Years of Age",
"has_exemption": false,
"start_date": "2024-04-05",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Sanofi Pasteur, a Sanofi Company",
"sponsor_slug": "sanofi-pasteur-a-sanofi-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06295159",
"publication_url": "https://clinicaltrials.gov/study/NCT06295159",
"title": "Neoadjuvant and Adjuvant Anti-PD1 or Combinations for Locoregionally Advanced Melanoma",
"has_exemption": false,
"start_date": "2024-05-17",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "H. Lee Moffitt Cancer Center and Research Institute",
"sponsor_slug": "h-lee-moffitt-cancer-center-and-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06284122",
"publication_url": "https://clinicaltrials.gov/study/NCT06284122",
"title": "A Phase III Randomized, Open-label, International, Multicenter Study Evaluating the Efficacy and Safety of Mosunetuzumab Plus Lenalidomide in Comparison to Anti-CD20 Monoclonal Antibody Plus Chemotherapy in Subjects With Previously Untreated FLIPI 2-5 Follicular Lymphoma",
"has_exemption": false,
"start_date": "2024-06-07",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "The Lymphoma Academic Research Organisation",
"sponsor_slug": "the-lymphoma-academic-research-organisation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05869682",
"publication_url": "https://clinicaltrials.gov/study/NCT05869682",
"title": "Phase 2 Study of Bright White Light During Treatment With ADT Combination Therapy in Men With Advanced Prostate Cancer to PreServe PHysIcal and MeNtal HEalth (SHINE)",
"has_exemption": false,
"start_date": "2024-07-09",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06535607",
"publication_url": "https://clinicaltrials.gov/study/NCT06535607",
"title": "A Phase II, Multi-Center Study to Evaluate the Efficacy and Safety of Volrustomig as Monotherapy or in Combination With Anti-cancer Agents in Participants With Advanced/Metastatic Solid Tumors",
"has_exemption": false,
"start_date": "2024-08-22",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06467305",
"publication_url": "https://clinicaltrials.gov/study/NCT06467305",
"title": "Sensorimotor Basis of Speech Motor Learning and Retention",
"has_exemption": false,
"start_date": "2024-10-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06491823",
"publication_url": "https://clinicaltrials.gov/study/NCT06491823",
"title": "Sensorimotor Basis of Speech Motor Learning and Retention",
"has_exemption": false,
"start_date": "2024-10-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06467292",
"publication_url": "https://clinicaltrials.gov/study/NCT06467292",
"title": "Sensorimotor Basis of Speech Motor Learning and Retention",
"has_exemption": false,
"start_date": "2024-10-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06487221",
"publication_url": "https://clinicaltrials.gov/study/NCT06487221",
"title": "A Phase II Trial of Avutometinib in Combination With Defactinib in Metastatic Diffuse Gastric Cancer",
"has_exemption": false,
"start_date": "2024-10-28",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Ryan H. Moy, MD, PhD",
"sponsor_slug": "ryan-h-moy-md-phd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06655896",
"publication_url": "https://clinicaltrials.gov/study/NCT06655896",
"title": "A Phase II, Multi-part, Randomized, Open-label, Assessor-blinded, Active-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Rapcabtagene Autoleucel Versus Rituximab Treatment in Participants With Severe Refractory Diffuse Cutaneous Systemic Sclerosis",
"has_exemption": false,
"start_date": "2024-10-29",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06399679",
"publication_url": "https://clinicaltrials.gov/study/NCT06399679",
"title": "Rivastigmine to Prevent Recurrence of Antimuscarinic Delirium After Initial Control With Physostigmine (RIVA-AP): a Randomized, Placebo-controlled Trial",
"has_exemption": false,
"start_date": "2024-11-04",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06111313",
"publication_url": "https://clinicaltrials.gov/study/NCT06111313",
"title": "A Phase 2 Risk Adapted Parallel Randomized Trial of MRI-Guided Lattice Stereotactic Focal Radiotherapy of the Prostate With or Without Ultra-Short Term Androgen Deprivation Therapy-The Miami UAdapt Trial",
"has_exemption": false,
"start_date": "2024-11-06",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Miami",
"sponsor_slug": "university-of-miami",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06703476",
"publication_url": "https://clinicaltrials.gov/study/NCT06703476",
"title": "A Clinically Integrated Randomized Clinical Trial (RCT) of Modifications to Radical Cystectomy and Postoperative Care",
"has_exemption": false,
"start_date": "2024-11-21",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06463457",
"publication_url": "https://clinicaltrials.gov/study/NCT06463457",
"title": "Comeback From Long coursE ADT With RElugolix and Darolutamide in Hormone-sensitive Prostate Cancer (CLEARED)",
"has_exemption": false,
"start_date": "2024-12-13",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Atish Choudhury, MD",
"sponsor_slug": "atish-choudhury-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06846541",
"publication_url": "https://clinicaltrials.gov/study/NCT06846541",
"title": "An Extension Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Long-term Safety, Efficacy, and Durability of Response to ESK-001",
"has_exemption": false,
"start_date": "2025-01-08",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Alumis Inc",
"sponsor_slug": "alumis-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06822738",
"publication_url": "https://clinicaltrials.gov/study/NCT06822738",
"title": "A Prospective, Multicenter Clinical Study to Evaluate the Safety and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Subjects With Glaucoma",
"has_exemption": false,
"start_date": "2025-02-11",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06829238",
"publication_url": "https://clinicaltrials.gov/study/NCT06829238",
"title": "Assessment of Metformin for Restoration of Immune Homeostasis in HIV+ and HIV- Individuals With a History of Injection Drug Use (MET-IH)",
"has_exemption": false,
"start_date": "2025-04-07",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07301177",
"publication_url": "https://clinicaltrials.gov/study/NCT07301177",
"title": "AtMS for Alleviating Posttraumatic Peripheral Neuropathic Pain (PTP-NP)",
"has_exemption": false,
"start_date": "2025-04-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Veterans Medical Research Foundation",
"sponsor_slug": "veterans-medical-research-foundation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06271590",
"publication_url": "https://clinicaltrials.gov/study/NCT06271590",
"title": "The MAGICAL SV Trial - A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Non Inferiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus-Coated Balloon in the Treatment of Small Vessels in Patients With Coronary Artery Disease.",
"has_exemption": false,
"start_date": "2025-05-20",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Concept Medical Inc.",
"sponsor_slug": "concept-medical-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07013110",
"publication_url": "https://clinicaltrials.gov/study/NCT07013110",
"title": "An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis - A Double-blind, Randomized, Placebo-controlled Clinical Trial",
"has_exemption": false,
"start_date": "2025-06-18",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Prof Salvatore Albani",
"sponsor_slug": "prof-salvatore-albani",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07064759",
"publication_url": "https://clinicaltrials.gov/study/NCT07064759",
"title": "A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration",
"has_exemption": false,
"start_date": "2025-07-22",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "4D Molecular Therapeutics",
"sponsor_slug": "4d-molecular-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07124910",
"publication_url": "https://clinicaltrials.gov/study/NCT07124910",
"title": "Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure Versus a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases",
"has_exemption": false,
"start_date": "2025-08-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Woolfson Eye Institute",
"sponsor_slug": "woolfson-eye-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07135167",
"publication_url": "https://clinicaltrials.gov/study/NCT07135167",
"title": "Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome",
"has_exemption": false,
"start_date": "2025-08-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Woolfson Eye Institute",
"sponsor_slug": "woolfson-eye-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07188844",
"publication_url": "https://clinicaltrials.gov/study/NCT07188844",
"title": "An Open-Label Extension Study to Assess Long-term Safety and Tolerability of Batoclimab in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)",
"has_exemption": false,
"start_date": "2025-08-28",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Immunovant Sciences GmbH",
"sponsor_slug": "immunovant-sciences-gmbh",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07047144",
"publication_url": "https://clinicaltrials.gov/study/NCT07047144",
"title": "A Phase 2, Double-Blind Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of Apitegromab in Subjects <2 Years Old With Spinal Muscular Atrophy (SMA)",
"has_exemption": false,
"start_date": "2025-09-15",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Scholar Rock, Inc.",
"sponsor_slug": "scholar-rock-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07222085",
"publication_url": "https://clinicaltrials.gov/study/NCT07222085",
"title": "Determining the Long-Term Stability of the Glide Control Strategy for Upper Limb Prostheses",
"has_exemption": false,
"start_date": "2025-10-15",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Infinite Biomedical Technologies",
"sponsor_slug": "infinite-biomedical-technologies",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07213804",
"publication_url": "https://clinicaltrials.gov/study/NCT07213804",
"title": "FRAmework-01: A Three-Part Phase 3 Study of Sofetabart Mipitecan (LY4170156) Versus Chemotherapy or Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer, and Sofetabart Mipitecan Plus Bevacizumab Versus Platinum-Based Chemotherapy Plus Bevacizumab in Platinum-Sensitive Ovarian Cancer.",
"has_exemption": false,
"start_date": "2025-10-22",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Eli Lilly and Company",
"sponsor_slug": "eli-lilly-and-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06793215",
"publication_url": "https://clinicaltrials.gov/study/NCT06793215",
"title": "A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2025-10-24",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06659445",
"publication_url": "https://clinicaltrials.gov/study/NCT06659445",
"title": "A Phase 2 Multicenter, Randomized, Double-masked, Sham-controlled, Reference-arm Study to Evaluate Efficacy and Safety of ONL1204 in Patients With Geographic Atrophy (GA) Associated With Age-related Macular Degeneration (AMD)",
"has_exemption": false,
"start_date": "2025-10-28",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "ONL Therapeutics",
"sponsor_slug": "onl-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07216742",
"publication_url": "https://clinicaltrials.gov/study/NCT07216742",
"title": "A Multicenter, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of a Human Menopausal Gonadotropin in the Development of Multiple Follicles, Pregnancy, and Cumulative Live Birth as Part of an Assisted Reproductive Technology (ART) Cycle.",
"has_exemption": false,
"start_date": "2025-11-01",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Granata Bio Corporation",
"sponsor_slug": "granata-bio-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07032792",
"publication_url": "https://clinicaltrials.gov/study/NCT07032792",
"title": "Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery",
"has_exemption": false,
"start_date": "2025-11-03",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Northwell Health",
"sponsor_slug": "northwell-health",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06455319",
"publication_url": "https://clinicaltrials.gov/study/NCT06455319",
"title": "Precision Administration of Anti-thymocyte Globulin With or Without Verapamil in Adolescents and Young Adults With Type 1 Diabetes",
"has_exemption": false,
"start_date": "2025-11-12",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Florida",
"sponsor_slug": "university-of-florida",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07387978",
"publication_url": "https://clinicaltrials.gov/study/NCT07387978",
"title": "A Pilot Study to Describe the Effect of Photobiomodulation in Reducing the Severity and Incidence of Oral Mucositis in Oral Cancer Patients Undergoing Radiation Treatment",
"has_exemption": false,
"start_date": "2025-11-26",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Peter MacCallum Cancer Centre, Australia",
"sponsor_slug": "peter-maccallum-cancer-centre-australia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07117669",
"publication_url": "https://clinicaltrials.gov/study/NCT07117669",
"title": "A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation and Expansion Study of ENP-501 in Non-Peanut Allergic Participants and Participants With a Known Peanut Allergy",
"has_exemption": false,
"start_date": "2025-12-16",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "N-Fold, LLC",
"sponsor_slug": "n-fold-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07228247",
"publication_url": "https://clinicaltrials.gov/study/NCT07228247",
"title": "A Phase Ⅰ/Ⅱa Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HMPL-A251 in Participants With Advanced or Metastatic HER2-Expressing Solid Tumors",
"has_exemption": false,
"start_date": "2025-12-16",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Hutchmed",
"sponsor_slug": "hutchmed",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06575075",
"publication_url": "https://clinicaltrials.gov/study/NCT06575075",
"title": "A Double-blind, Placebo-controlled Study to Determine the Safety and Feasibility of Two Doses of Intravenous (2R, 6R)-Hydroxynorketamine (RR-HNK) in Adults With Obsessive-Compulsive Disorder",
"has_exemption": false,
"start_date": "2026-01-23",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Carolyn Rodriguez",
"sponsor_slug": "carolyn-rodriguez",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07091279",
"publication_url": "https://clinicaltrials.gov/study/NCT07091279",
"title": "Randomized Controlled Trial of Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism",
"has_exemption": false,
"start_date": "2026-01-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Jeremy Veenstra-vanderweele",
"sponsor_slug": "jeremy-veenstra-vanderweele",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07344220",
"publication_url": "https://clinicaltrials.gov/study/NCT07344220",
"title": "Metastatic Non-Familial Adenocarcinoma Maintenance Therapy With DZ-002: Heptamine Carboxymethine Dye Conjugate",
"has_exemption": false,
"start_date": "2026-01-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoag Memorial Hospital Presbyterian",
"sponsor_slug": "hoag-memorial-hospital-presbyterian",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07424378",
"publication_url": "https://clinicaltrials.gov/study/NCT07424378",
"title": "Randomized Controlled Trial of Epoprostenol Versus Placebo in Addition to Standard Therapy for Severe Frostbite Injury",
"has_exemption": false,
"start_date": "2026-02-28",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Colorado, Denver",
"sponsor_slug": "university-of-colorado-denver",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06434064",
"publication_url": "https://clinicaltrials.gov/study/NCT06434064",
"title": "A Pilot, Single-Arm, Phase II Trial of Tamoxifen Plus Pegylated Liposomal Doxorubicin in Patients With Metastatic Triple Negative Breast Cancer",
"has_exemption": false,
"start_date": "2026-03-03",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Roswell Park Cancer Institute",
"sponsor_slug": "roswell-park-cancer-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07227025",
"publication_url": "https://clinicaltrials.gov/study/NCT07227025",
"title": "A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Olomorasib Combination Therapy in Metastatic Non-small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2026-03-03",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07407933",
"publication_url": "https://clinicaltrials.gov/study/NCT07407933",
"title": "A Phase Ib/II, Multicenter, Open-Label Study to Evaluate Safety, Efficacy, and Pharmacokinetics of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2026-03-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "MediLink Therapeutics (Suzhou) Co., Ltd.",
"sponsor_slug": "medilink-therapeutics-suzhou-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07107334",
"publication_url": "https://clinicaltrials.gov/study/NCT07107334",
"title": "A Pilot Study to Estimate Early Clinical Efficacy Signals of a Glucagon-like Peptide 1 Receptor Agonist (GLP-1RA) Administration in Conjunction With Levonorgestrel Intrauterine Device (LNG-IUD) in Obese Patients With Endometrioid Intraepithelial Neoplasia",
"has_exemption": false,
"start_date": "2026-04-07",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Florida",
"sponsor_slug": "university-of-florida",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07133074",
"publication_url": "https://clinicaltrials.gov/study/NCT07133074",
"title": "Optimizing Antibiotic Selection in Hematologic Malignancy Patients With Reported Beta-lactam Allergy - Intervention",
"has_exemption": false,
"start_date": "2026-04-20",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Abramson Cancer Center at Penn Medicine",
"sponsor_slug": "abramson-cancer-center-at-penn-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07428746",
"publication_url": "https://clinicaltrials.gov/study/NCT07428746",
"title": "Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes",
"has_exemption": false,
"start_date": "2026-04-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Emory University",
"sponsor_slug": "emory-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07326566",
"publication_url": "https://clinicaltrials.gov/study/NCT07326566",
"title": "A Phase 2 Randomized, Multicenter Study to Evaluate the Efficacy and Safety of Silevertinib, an Oral EGFR Inhibitor, in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter and EGFRvIII",
"has_exemption": false,
"start_date": "2026-05-05",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Black Diamond Therapeutics, Inc.",
"sponsor_slug": "black-diamond-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07571135",
"publication_url": "https://clinicaltrials.gov/study/NCT07571135",
"title": "Letermovir Versus Valganciclovir for 90 Days in CMV Seropositive Kidney Transplant Recipients: Results of a Single-center Experience.",
"has_exemption": false,
"start_date": "2026-05-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Elisabeth Kincaide",
"sponsor_slug": "elisabeth-kincaide",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07673107",
"publication_url": "https://clinicaltrials.gov/study/NCT07673107",
"title": "A Phase 2b Multicenter, Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label Period to Evaluate the Efficacy and Safety of AGN-151607-DP (USAN: gemibotulinumtoxinA) for the Treatment of Upper Limb Essential Tremor in Adults",
"has_exemption": false,
"start_date": "2026-06-18",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06210854",
"publication_url": "https://clinicaltrials.gov/study/NCT06210854",
"title": "Double-Blind Randomized Phase II Clinical Trial Assessing Administration of pBI-11 Via Electroporation for the Treatment of Patients With HPV16/18+ <CIN2",
"has_exemption": false,
"start_date": "2026-06-25",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins",
"sponsor_slug": "sidney-kimmel-comprehensive-cancer-center-at-johns-hopkins",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06382649",
"publication_url": "https://clinicaltrials.gov/study/NCT06382649",
"title": "Rivastigmine for Antimuscarinic Delirium: a Randomized, Placebo-controlled Trial",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07527299",
"publication_url": "https://clinicaltrials.gov/study/NCT07527299",
"title": "Assessment of the Safety and Effectiveness of the VARIPULSE™ Catheter System in the Treatment of Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein (With or Without Posterior Wall Isolation) and Superior Vena Cava Isolation: A Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2026-08-05",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Biosense Webster, Inc.",
"sponsor_slug": "biosense-webster-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07393555",
"publication_url": "https://clinicaltrials.gov/study/NCT07393555",
"title": "A Randomized Phase II Study of Sacituzumab Govitecan Alone, Ivonescimab Alone, or Sacituzumab Govitecan and Ivonescimab in Participants With Previously-Treated Actionable Genomic Alteration Positive Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Sub-Study)",
"has_exemption": false,
"start_date": "2026-08-07",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "SWOG Cancer Research Network",
"sponsor_slug": "swog-cancer-research-network",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06458907",
"publication_url": "https://clinicaltrials.gov/study/NCT06458907",
"title": "A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.",
"has_exemption": false,
"start_date": "2026-08-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "P+F Products + Features USA Inc.",
"sponsor_slug": "pf-products-features-usa-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07650201",
"publication_url": "https://clinicaltrials.gov/study/NCT07650201",
"title": "A Prospective, Multicenter, Open-label, Single-arm Clinical Trial to Investigate the Safety and Effectiveness of the KI-362-US1 (YP2.2VM) IOL for Correction of Aphakia Following Cataract Extraction",
"has_exemption": false,
"start_date": "2026-08-31",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Kowa Research Institute, Inc.",
"sponsor_slug": "kowa-research-institute-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07570654",
"publication_url": "https://clinicaltrials.gov/study/NCT07570654",
"title": "A Phase 2b/3, Multicentre, Randomised, Double-blind, Controlled Trial, With an Open Label Extension, to Investigate the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder",
"has_exemption": false,
"start_date": "2026-09-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "COMPASS Pathways",
"sponsor_slug": "compass-pathways",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07581197",
"publication_url": "https://clinicaltrials.gov/study/NCT07581197",
"title": "A Phase 1/2 Dose Escalation Study to Evaluate the Safety and Efficacy of SR-02 Pancreatic Endocrine Cell Clusters Implanted in the Omentum of Adults With Type 1 Diabetes (SUGR)",
"has_exemption": false,
"start_date": "2026-11-30",
"completion_date": "2028-11-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Seraxis",
"sponsor_slug": "seraxis",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03148106",
"publication_url": "https://clinicaltrials.gov/study/NCT03148106",
"title": "Optimizing Peripheral Stimulation Parameters to Modulate the Sensorimotor Cortex for Post-stroke Motor Recovery.",
"has_exemption": false,
"start_date": "2017-04-04",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Francisco",
"sponsor_slug": "university-of-california-san-francisco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03217110",
"publication_url": "https://clinicaltrials.gov/study/NCT03217110",
"title": "Cerebellar Transcranial Magnetic Stimulation and Cognitive Control",
"has_exemption": false,
"start_date": "2017-11-30",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Krystal Parker, PhD",
"sponsor_slug": "krystal-parker-phd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04303117",
"publication_url": "https://clinicaltrials.gov/study/NCT04303117",
"title": "Phase I/II Study of PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma",
"has_exemption": false,
"start_date": "2020-07-13",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04588077",
"publication_url": "https://clinicaltrials.gov/study/NCT04588077",
"title": "Comparison the Seroconversion Rate Between Two-dose and Three-dose Regimens of Heplisav B Among Patients With Cirrhosis, a Randomized-control Prospective Study.",
"has_exemption": false,
"start_date": "2020-09-14",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Mercy Medical Center",
"sponsor_slug": "mercy-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04825522",
"publication_url": "https://clinicaltrials.gov/study/NCT04825522",
"title": "The Effect of Intrawound Vancomycin Powder in Spine Surgery: A Prospective Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2022-03-27",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Windsor-Essex Compassionate Care Community",
"sponsor_slug": "windsor-essex-compassionate-care-community",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05303519",
"publication_url": "https://clinicaltrials.gov/study/NCT05303519",
"title": "A Phase 3, Multicenter, Clinical Study to Evaluate the Efficacy and Safety of Safusidenib Erbumine in Participants With Isocitrate Dehydrogenase 1 (IDH1)-Mutant Glioma",
"has_exemption": false,
"start_date": "2023-06-05",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Nuvation Bio, Inc.",
"sponsor_slug": "nuvation-bio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06082947",
"publication_url": "https://clinicaltrials.gov/study/NCT06082947",
"title": "αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT) for Children and Young Adults With Hematologic Malignancies",
"has_exemption": false,
"start_date": "2023-12-18",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Nationwide Children's Hospital",
"sponsor_slug": "nationwide-childrens-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06168942",
"publication_url": "https://clinicaltrials.gov/study/NCT06168942",
"title": "LAM202403: Laminar Left Atrial Appendage Elimination (LAAX) Pivotal IDE Study",
"has_exemption": false,
"start_date": "2024-02-19",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Biosense Webster, Inc.",
"sponsor_slug": "biosense-webster-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06312813",
"publication_url": "https://clinicaltrials.gov/study/NCT06312813",
"title": "Pilot Studies Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea",
"has_exemption": false,
"start_date": "2024-02-27",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Wright State University",
"sponsor_slug": "wright-state-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06150417",
"publication_url": "https://clinicaltrials.gov/study/NCT06150417",
"title": "Metastasis-directed Radiotherapy (MDRT) for Men With De-novo Oligometastatic Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)",
"has_exemption": false,
"start_date": "2024-07-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Case Comprehensive Cancer Center",
"sponsor_slug": "case-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06282575",
"publication_url": "https://clinicaltrials.gov/study/NCT06282575",
"title": "An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer",
"has_exemption": false,
"start_date": "2024-07-19",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Jazz Pharmaceuticals",
"sponsor_slug": "jazz-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06493370",
"publication_url": "https://clinicaltrials.gov/study/NCT06493370",
"title": "Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer",
"has_exemption": false,
"start_date": "2025-01-16",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Kansas Medical Center",
"sponsor_slug": "university-of-kansas-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06216535",
"publication_url": "https://clinicaltrials.gov/study/NCT06216535",
"title": "Escitalopram in Asthma Patients With Frequent Exacerbation",
"has_exemption": false,
"start_date": "2025-05-19",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas Southwestern Medical Center",
"sponsor_slug": "university-of-texas-southwestern-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07258446",
"publication_url": "https://clinicaltrials.gov/study/NCT07258446",
"title": "PRAME (Preferentially Expressed Antigen in Melanoma) Immunohistochemistry Guided Slow-Mohs Micrographic Surgery of Malignant Melanoma: A Pragmatic Clinical Trial",
"has_exemption": false,
"start_date": "2025-10-24",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, Davis",
"sponsor_slug": "university-of-california-davis",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06419439",
"publication_url": "https://clinicaltrials.gov/study/NCT06419439",
"title": "Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression",
"has_exemption": false,
"start_date": "2025-12-03",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "VA Office of Research and Development",
"sponsor_slug": "va-office-of-research-and-development",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07226856",
"publication_url": "https://clinicaltrials.gov/study/NCT07226856",
"title": "Phase 2, Single-Arm Trial of BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-Paclitaxel in the First Line Setting of Advanced Pancreatic Adenocarcinoma",
"has_exemption": false,
"start_date": "2025-12-12",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07280169",
"publication_url": "https://clinicaltrials.gov/study/NCT07280169",
"title": "Identifying Non-Union Rates Using Carbo-fix Lateral Plate Devices and Standard Plate-Nail Construct in Distal Femur Fractures",
"has_exemption": false,
"start_date": "2026-01-29",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Missouri-Columbia",
"sponsor_slug": "university-of-missouri-columbia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07237048",
"publication_url": "https://clinicaltrials.gov/study/NCT07237048",
"title": "Effect of Oral Minocycline in Patients With Acute Stroke - a Randomized, Open Label, Prospective Trial",
"has_exemption": false,
"start_date": "2026-02-02",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Joyce Chen",
"sponsor_slug": "joyce-chen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07199192",
"publication_url": "https://clinicaltrials.gov/study/NCT07199192",
"title": "A Multicenter, Randomized, Controlled Trial to Evaluate the Effectiveness and Safety of Systemic Corticosteroid Treatment for Hospitalized Patients With Severe Acute Respiratory Infection and Hypoxemia (STRIVE 003)",
"has_exemption": false,
"start_date": "2026-03-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "National Institute of Allergy and Infectious Diseases (NIAID)",
"sponsor_slug": "national-institute-of-allergy-and-infectious-diseases-niaid",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07017829",
"publication_url": "https://clinicaltrials.gov/study/NCT07017829",
"title": "A Phase II Trial of GT103 in Combination With Pembrolizumab in STK11 Mutant Non-Small Cell Lung Cancer (NSCLC)",
"has_exemption": false,
"start_date": "2026-04-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Roswell Park Cancer Institute",
"sponsor_slug": "roswell-park-cancer-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06965504",
"publication_url": "https://clinicaltrials.gov/study/NCT06965504",
"title": "Initiation and Titration of Guideline Directed Medical Therapy in Heart Failure Cardiogenic Shock With Impella 5.5 for Cardiac Recovery: INTeGRATE",
"has_exemption": false,
"start_date": "2026-04-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Abiomed Inc.",
"sponsor_slug": "abiomed-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07463521",
"publication_url": "https://clinicaltrials.gov/study/NCT07463521",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Ocular Myasthenia Gravis",
"has_exemption": false,
"start_date": "2026-05-27",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "UCB Biopharma SRL",
"sponsor_slug": "ucb-biopharma-srl",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07095894",
"publication_url": "https://clinicaltrials.gov/study/NCT07095894",
"title": "A Randomized Placebo-controlled Trial of Spectacles With Highly Aspherical Lenslet Target (H.A.L.T.) MAX Technology or 0.05% Atropine to Slow Progression of Myopia in Children",
"has_exemption": false,
"start_date": "2026-06-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Jaeb Center for Health Research",
"sponsor_slug": "jaeb-center-for-health-research",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07680946",
"publication_url": "https://clinicaltrials.gov/study/NCT07680946",
"title": "Evaluating Safety and Efficacy of Ublituximab in Participants With Schizophrenia",
"has_exemption": false,
"start_date": "2026-07-06",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "TG Therapeutics, Inc.",
"sponsor_slug": "tg-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07535489",
"publication_url": "https://clinicaltrials.gov/study/NCT07535489",
"title": "A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of IPG11406 Tablets in Adult Patients With Moderately to Severely Active Ulcerative Colitis",
"has_exemption": false,
"start_date": "2026-07-07",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Nanjing Immunophage Biotech Co., Ltd",
"sponsor_slug": "nanjing-immunophage-biotech-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07228195",
"publication_url": "https://clinicaltrials.gov/study/NCT07228195",
"title": "SGLT2i Therapy in Islet Transplantation (SIT)",
"has_exemption": false,
"start_date": "2026-07-15",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Minnesota",
"sponsor_slug": "university-of-minnesota",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07686068",
"publication_url": "https://clinicaltrials.gov/study/NCT07686068",
"title": "Phase 1/2a Open-Label Clinical Trial Evaluating VBC106, an FRα- and MSLN-Directed Bispecific Antibody Drug Conjugate, in Participants With Advanced Malignant Solid Tumors",
"has_exemption": false,
"start_date": "2026-08-18",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "VelaVigo Bio Inc",
"sponsor_slug": "velavigo-bio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07349693",
"publication_url": "https://clinicaltrials.gov/study/NCT07349693",
"title": "A Randomized Trial to Assess the Efficacy and Safety of Cerebraca Wafer Plus Temozolomide Versus Temozolomide Alone in Recurrent Glioblastoma",
"has_exemption": false,
"start_date": "2026-11-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Everfront Biotech Co., Ltd.",
"sponsor_slug": "everfront-biotech-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03787290",
"publication_url": "https://clinicaltrials.gov/study/NCT03787290",
"title": "Examining Immune-Based Mechanisms of Action for Mild-Intensity Whole Body Hyperthermia (WBH) in the Treatment of Major Depressive Disorder",
"has_exemption": false,
"start_date": "2026-12-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07274787",
"publication_url": "https://clinicaltrials.gov/study/NCT07274787",
"title": "An Open Label, Prospective, Pilot Study To Evaluate The Safety And Effectiveness Of The NaviFUS System In Conjunction With A Standard Treatment Regimen Of Bevacizumab (BEV) In Patients With Recurrent Glioblastoma",
"has_exemption": false,
"start_date": "2026-12-01",
"completion_date": "2028-12-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Cincinnati",
"sponsor_slug": "university-of-cincinnati",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06634589",
"publication_url": "https://clinicaltrials.gov/study/NCT06634589",
"title": "A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies",
"has_exemption": false,
"start_date": "2024-11-27",
"completion_date": "2028-12-02",
"has_results": false,
"results_due": false,
"sponsor_name": "BeOne Medicines",
"sponsor_slug": "beone-medicines",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05205174",
"publication_url": "https://clinicaltrials.gov/study/NCT05205174",
"title": "Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury",
"has_exemption": false,
"start_date": "2025-04-03",
"completion_date": "2028-12-03",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Minnesota",
"sponsor_slug": "university-of-minnesota",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06130553",
"publication_url": "https://clinicaltrials.gov/study/NCT06130553",
"title": "PRIMROSE: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced/Metastatic Solid Tumors That Are MTAP Deficient",
"has_exemption": false,
"start_date": "2024-01-18",
"completion_date": "2028-12-04",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07134088",
"publication_url": "https://clinicaltrials.gov/study/NCT07134088",
"title": "A Phase 1b/2 Study to Investigate the Safety, Efficacy and Pharmacokinetics of Administration of Subcutaneous (SC) Blinatumomab in Pediatric Participants With Relapsed/Refractory (R/R) and Minimal Residual Disease Positive (MRD+) B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL)",
"has_exemption": false,
"start_date": "2025-12-08",
"completion_date": "2028-12-05",
"has_results": false,
"results_due": false,
"sponsor_name": "Amgen",
"sponsor_slug": "amgen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07540988",
"publication_url": "https://clinicaltrials.gov/study/NCT07540988",
"title": "A Double-blind, Randomized, Placebo-controlled Trial Investigating the Efficacy and Safety of Nerandomilast Over at Least 52 Weeks in Patients With Fibrosing Interstitial Lung Disease at Risk for Disease Progression (FIBRONEER-ACT)",
"has_exemption": false,
"start_date": "2026-08-28",
"completion_date": "2028-12-05",
"has_results": false,
"results_due": false,
"sponsor_name": "Boehringer Ingelheim",
"sponsor_slug": "boehringer-ingelheim",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07438496",
"publication_url": "https://clinicaltrials.gov/study/NCT07438496",
"title": "A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus",
"has_exemption": false,
"start_date": "2026-03-05",
"completion_date": "2028-12-06",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07569081",
"publication_url": "https://clinicaltrials.gov/study/NCT07569081",
"title": "A Randomized Phase 2/3, Double-blind, Placebo Controlled Adaptive Study Evaluating the Efficacy and Safety of Momelotinib in Participants With VEXAS Syndrome",
"has_exemption": false,
"start_date": "2026-08-05",
"completion_date": "2028-12-06",
"has_results": false,
"results_due": false,
"sponsor_name": "GlaxoSmithKline",
"sponsor_slug": "glaxosmithkline",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07218029",
"publication_url": "https://clinicaltrials.gov/study/NCT07218029",
"title": "An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-038)",
"has_exemption": false,
"start_date": "2021-05-12",
"completion_date": "2028-12-07",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06596694",
"publication_url": "https://clinicaltrials.gov/study/NCT06596694",
"title": "A Phase 1/2 Study to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Gastrointestinal Cancers",
"has_exemption": false,
"start_date": "2024-11-03",
"completion_date": "2028-12-07",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07625306",
"publication_url": "https://clinicaltrials.gov/study/NCT07625306",
"title": "A Randomized, Double-blind, Placebo-controlled, Multicenter Study Evaluating the Efficacy, Safety, Tolerability, and Coronary Plaque Effects of Early Pelacarsen (TQJ230) Initiation in Patients in the US With Elevated Lp(a) and Recent Acute Coronary Syndrome",
"has_exemption": false,
"start_date": "2026-08-31",
"completion_date": "2028-12-07",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05083169",
"publication_url": "https://clinicaltrials.gov/study/NCT05083169",
"title": "A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma",
"has_exemption": false,
"start_date": "2021-10-14",
"completion_date": "2028-12-08",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06784752",
"publication_url": "https://clinicaltrials.gov/study/NCT06784752",
"title": "A Phase III Multi-center, Randomized, Open-label Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients Newly Diagnosed With Grade 1 and Grade 2 (Ki-67 <10%) Advanced GEP-NET With High Disease Burden (NETTER-3)",
"has_exemption": false,
"start_date": "2025-05-30",
"completion_date": "2028-12-08",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07559513",
"publication_url": "https://clinicaltrials.gov/study/NCT07559513",
"title": "Phase 3 Evaluation of the Safety, Pharmacokinetics, and Efficacy of Garetosmab (Anti-Activin A Monoclonal Antibody) in Children and Adolescents With Fibrodysplasia Ossificans Progressiva",
"has_exemption": false,
"start_date": "2026-07-30",
"completion_date": "2028-12-10",
"has_results": false,
"results_due": false,
"sponsor_name": "Regeneron Pharmaceuticals",
"sponsor_slug": "regeneron-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06093126",
"publication_url": "https://clinicaltrials.gov/study/NCT06093126",
"title": "Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial",
"has_exemption": false,
"start_date": "2023-12-11",
"completion_date": "2028-12-11",
"has_results": false,
"results_due": false,
"sponsor_name": "Nova Scotia Health Authority",
"sponsor_slug": "nova-scotia-health-authority",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07282665",
"publication_url": "https://clinicaltrials.gov/study/NCT07282665",
"title": "A PHASE 3, PLACEBO-CONTROLLED, DOUBLE-BLINDED, RANDOMIZED STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF A CLOSTRIDIOIDES DIFFICILE VACCINE IN ADULTS 65 YEARS OF AGE AND OLDER",
"has_exemption": false,
"start_date": "2025-12-10",
"completion_date": "2028-12-11",
"has_results": false,
"results_due": false,
"sponsor_name": "Pfizer",
"sponsor_slug": "pfizer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07646821",
"publication_url": "https://clinicaltrials.gov/study/NCT07646821",
"title": "A Phase 1b/2 Study of Ropeginterferon Alfa-2b Added to Azacitidine in Newly Diagnosed MDS/AML (≥ 10% Blasts) With TP53 Mutations",
"has_exemption": false,
"start_date": "2026-11-27",
"completion_date": "2028-12-11",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07258511",
"publication_url": "https://clinicaltrials.gov/study/NCT07258511",
"title": "A Phase 3 Randomized Study Comparing JNJ-79635322 and an Anti-BCMAxCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti CD38 Antibody",
"has_exemption": false,
"start_date": "2026-02-04",
"completion_date": "2028-12-12",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07424144",
"publication_url": "https://clinicaltrials.gov/study/NCT07424144",
"title": "A Double-blinded Extension Study to Evaluate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Who Participated in Either EFC18418 or EFC18419 Clinical Studies",
"has_exemption": false,
"start_date": "2026-03-12",
"completion_date": "2028-12-12",
"has_results": false,
"results_due": false,
"sponsor_name": "Sanofi",
"sponsor_slug": "sanofi",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07400107",
"publication_url": "https://clinicaltrials.gov/study/NCT07400107",
"title": "Efficacy and Safety of NNC0487-0111 s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Overweight or Obesity, and Type 2 Diabetes (AMAZE 8)",
"has_exemption": false,
"start_date": "2026-05-20",
"completion_date": "2028-12-12",
"has_results": false,
"results_due": false,
"sponsor_name": "Novo Nordisk A/S",
"sponsor_slug": "novo-nordisk-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06952660",
"publication_url": "https://clinicaltrials.gov/study/NCT06952660",
"title": "A PROSPECTIVE LOW-INTERVENTIONAL PHASE 4 SINGLE ARM STUDY OF OCULAR ASSESSMENTS IN PATIENTS TREATED WITH TIVDAK® IN RECURRENT OR METASTATIC CERVICAL CANCER",
"has_exemption": false,
"start_date": "2025-05-07",
"completion_date": "2028-12-13",
"has_results": false,
"results_due": false,
"sponsor_name": "Pfizer",
"sponsor_slug": "pfizer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07386002",
"publication_url": "https://clinicaltrials.gov/study/NCT07386002",
"title": "A Phase II, Open-Label, Multicenter Study With a Safety Run-In to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of MT027 Administrated Intracerebroventricularly in Patients With Recurrent or Progressive Glioblastoma (WHO Grade 4)",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2028-12-13",
"has_results": false,
"results_due": false,
"sponsor_name": "T-MAXIMUM Pharmaceutical Inc",
"sponsor_slug": "t-maximum-pharmaceutical-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07513181",
"publication_url": "https://clinicaltrials.gov/study/NCT07513181",
"title": "A Phase 2b, Double-Blind, Placebo-Controlled, Multicenter Proof of Concept Clinical Study to Evaluate the Efficacy and Safety of ATH-063 Induction Therapy in Patients With Biologic Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC)",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2028-12-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Athos Therapeutics Inc",
"sponsor_slug": "athos-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06662786",
"publication_url": "https://clinicaltrials.gov/study/NCT06662786",
"title": "A Randomized, Open-label Phase 3 Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer",
"has_exemption": false,
"start_date": "2024-10-18",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07100080",
"publication_url": "https://clinicaltrials.gov/study/NCT07100080",
"title": "IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy",
"has_exemption": false,
"start_date": "2025-11-05",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Bristol-Myers Squibb",
"sponsor_slug": "bristol-myers-squibb",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07281716",
"publication_url": "https://clinicaltrials.gov/study/NCT07281716",
"title": "A Phase 1b/2 Study of Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC)",
"has_exemption": false,
"start_date": "2025-12-01",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Dan Feng",
"sponsor_slug": "dan-feng",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07293754",
"publication_url": "https://clinicaltrials.gov/study/NCT07293754",
"title": "A Phase 1/2 Trial of RPTR-1-201, a T Cell Receptor Bispecific Therapy, in Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2025-12-12",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Repertoire Immune Medicines",
"sponsor_slug": "repertoire-immune-medicines",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07282587",
"publication_url": "https://clinicaltrials.gov/study/NCT07282587",
"title": "A Phase 2 Study of ONC206 in Advanced Pheochromocytoma and Paraganglioma",
"has_exemption": false,
"start_date": "2026-01-02",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Jazz Pharmaceuticals",
"sponsor_slug": "jazz-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07566429",
"publication_url": "https://clinicaltrials.gov/study/NCT07566429",
"title": "A Phase 2, Open-label, Single Group, Fixed-dose Study to Evaluate the Safety and Efficacy of a Single Bilateral Intraputaminal Administration of AB-1005 (AAV2-GDNF Gene Therapy) in Japanese Participants With Moderate Stage Parkinson's Disease",
"has_exemption": false,
"start_date": "2026-07-27",
"completion_date": "2028-12-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Bayer",
"sponsor_slug": "bayer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06572423",
"publication_url": "https://clinicaltrials.gov/study/NCT06572423",
"title": "Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy for Palliative Head and Neck Cancer Treatment (PULS-Pal)",
"has_exemption": false,
"start_date": "2024-10-25",
"completion_date": "2028-12-16",
"has_results": false,
"results_due": false,
"sponsor_name": "Jonsson Comprehensive Cancer Center",
"sponsor_slug": "jonsson-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05790213",
"publication_url": "https://clinicaltrials.gov/study/NCT05790213",
"title": "Phase II Trial of Focal Prostate Ablation Combined With Androgen Deprivation Therapy for Prostate Cancer Treatment",
"has_exemption": false,
"start_date": "2025-05-05",
"completion_date": "2028-12-18",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Chicago",
"sponsor_slug": "university-of-chicago",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07405476",
"publication_url": "https://clinicaltrials.gov/study/NCT07405476",
"title": "A Phase II Clinical Trial of Neoadjuvant Zanidatamab for HER2+ Localized Colorectal Cancer",
"has_exemption": false,
"start_date": "2026-04-07",
"completion_date": "2028-12-18",
"has_results": false,
"results_due": false,
"sponsor_name": "Emory University",
"sponsor_slug": "emory-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07634601",
"publication_url": "https://clinicaltrials.gov/study/NCT07634601",
"title": "A Phase II Study of Elacestrant, an Oral Selective Estrogen Receptor Degrader (SERD) Combined With Everolimus in Patients With Recurrent or Metastatic ER-Positive (ER+) Endometrial Cancer (ELAVERA)",
"has_exemption": false,
"start_date": "2026-12-18",
"completion_date": "2028-12-18",
"has_results": false,
"results_due": false,
"sponsor_name": "Jonsson Comprehensive Cancer Center",
"sponsor_slug": "jonsson-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05334368",
"publication_url": "https://clinicaltrials.gov/study/NCT05334368",
"title": "A Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Depemokimab in Adults With Hypereosinophilic Syndrome (HES)",
"has_exemption": false,
"start_date": "2022-09-06",
"completion_date": "2028-12-19",
"has_results": false,
"results_due": false,
"sponsor_name": "GlaxoSmithKline",
"sponsor_slug": "glaxosmithkline",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07405801",
"publication_url": "https://clinicaltrials.gov/study/NCT07405801",
"title": "A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Patients With Endocrine- Resistant Hormone-Receptor-Positive, HER2-Negative Advanced Breast Cancer With Chromosome 8P Loss and Without a PIK3CA Mutation",
"has_exemption": false,
"start_date": "2026-04-07",
"completion_date": "2028-12-19",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05723926",
"publication_url": "https://clinicaltrials.gov/study/NCT05723926",
"title": "Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation",
"has_exemption": false,
"start_date": "2026-01-09",
"completion_date": "2028-12-20",
"has_results": false,
"results_due": false,
"sponsor_name": "Javelin Medical",
"sponsor_slug": "javelin-medical",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06858501",
"publication_url": "https://clinicaltrials.gov/study/NCT06858501",
"title": "Concordance in Response Assessment Incorporating Meta-Iodobenzylguanidine (123I-MIBG) and Meta-[18F]Fluorobenzylguanidine (18F-MFBG, IND#146379, NSC#853868) Imaging in Neuroblastoma",
"has_exemption": false,
"start_date": "2026-09-22",
"completion_date": "2028-12-20",
"has_results": false,
"results_due": false,
"sponsor_name": "Children's Oncology Group",
"sponsor_slug": "childrens-oncology-group",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04468659",
"publication_url": "https://clinicaltrials.gov/study/NCT04468659",
"title": "AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm, 216 Week Study With an Extension Phase to Evaluate Efficacy and Safety of Treatment With BAN2401 in Subjects With Preclinical Alzheimer's Disease and Elevated Amyloid (A45 Trial) and in Subjects With Early Preclinical Alzheimer's Disease and Intermediate Amyloid (A3 Trial)",
"has_exemption": false,
"start_date": "2020-07-14",
"completion_date": "2028-12-21",
"has_results": false,
"results_due": false,
"sponsor_name": "Eisai Inc.",
"sponsor_slug": "eisai-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06191315",
"publication_url": "https://clinicaltrials.gov/study/NCT06191315",
"title": "A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Assess the Efficacy and Longterm Safety of Dupilumab in Children 2 to <6 Years of Age With Uncontrolled Asthma and/or Recurrent Severe Asthmatic Wheeze",
"has_exemption": false,
"start_date": "2024-01-03",
"completion_date": "2028-12-21",
"has_results": false,
"results_due": false,
"sponsor_name": "Sanofi",
"sponsor_slug": "sanofi",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07053423",
"publication_url": "https://clinicaltrials.gov/study/NCT07053423",
"title": "A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Dupilumab on Airway Inflammation Through Assessments of Mucus Plugging and Other Lung Imaging Parameters in Patients With Chronic Obstructive Pulmonary Disease.",
"has_exemption": false,
"start_date": "2025-09-22",
"completion_date": "2028-12-23",
"has_results": false,
"results_due": false,
"sponsor_name": "Sanofi",
"sponsor_slug": "sanofi",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07205718",
"publication_url": "https://clinicaltrials.gov/study/NCT07205718",
"title": "An Open-label, Dose Escalation and Expansion, Phase 1/2 Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TAK- 188, an Anti-CCR8 Antibody-Drug- Conjugate, as a Single Agent in Adult Participants With Locally Advanced or Metastatic Solid Tumors",
"has_exemption": false,
"start_date": "2025-11-19",
"completion_date": "2028-12-26",
"has_results": false,
"results_due": false,
"sponsor_name": "Takeda",
"sponsor_slug": "takeda",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT01174121",
"publication_url": "https://clinicaltrials.gov/study/NCT01174121",
"title": "A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab",
"has_exemption": false,
"start_date": "2010-08-26",
"completion_date": "2028-12-27",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT07220083",
"publication_url": "https://clinicaltrials.gov/study/NCT07220083",
"title": "A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled Trial to Assess the Effects of Oral TRPC6 Inhibitor BI 764198 Taken Over a 104 Week Treatment Period in Adult and Adolescent Participants With Primary Focal Segmental Glomerulosclerosis (pFSGS) or Genetic FSGS Related to TRPC6 Gene Variants",
"has_exemption": false,
"start_date": "2026-02-16",
"completion_date": "2028-12-27",
"has_results": false,
"results_due": false,
"sponsor_name": "Boehringer Ingelheim",
"sponsor_slug": "boehringer-ingelheim",
"status": "ongoing",
"is_pact": false,
"days_late": null
}
]
}