HTTP 200 OK
Allow: GET, POST, HEAD, OPTIONS
Content-Type: application/json
Vary: Accept
{
"recordsFiltered": 45649,
"recordsTotal": 45649,
"next": "http://staging-fdaaa.ebmdatalab.net/api/trials/?format=api&length=300&ordering=sponsor__name&start=43200",
"previous": "http://staging-fdaaa.ebmdatalab.net/api/trials/?format=api&length=300&ordering=sponsor__name&start=42600",
"results": [
{
"registry_id": "NCT06578156",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06578156",
"title": "Physiologic Effects of Nasal High Flow on Exercise Tolerance in Chronic Obstructive Pulmonary Disease (COPD)",
"has_exemption": false,
"start_date": "2024-12-12",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Miami",
"sponsor_slug": "university-of-miami",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06741085",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06741085",
"title": "ICON-RT: Intracranial Consolidation and Deferral of Radiation Therapy in Patients Receiving Approved CNS-Active Systemic Therapeutics",
"has_exemption": false,
"start_date": "2024-12-13",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06771544",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06771544",
"title": "Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma",
"has_exemption": false,
"start_date": "2024-12-23",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, Irvine",
"sponsor_slug": "university-of-california-irvine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06756308",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06756308",
"title": "A Phase 2 Study of Enasidenib in IDH2-Mutant Angioimmunoblastic T-Cell Lymphoma",
"has_exemption": false,
"start_date": "2024-12-24",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06390319",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06390319",
"title": "SJALL23T: Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)",
"has_exemption": false,
"start_date": "2024-12-27",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "St. Jude Children's Research Hospital",
"sponsor_slug": "st-jude-childrens-research-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06752616",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06752616",
"title": "Advancing the Quality of Treatment and Care for Acute Agitation in Emergency Psychiatry",
"has_exemption": false,
"start_date": "2024-12-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Lone Baandrup",
"sponsor_slug": "lone-baandrup",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06694350",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06694350",
"title": "Safety and Efficacy of Pembrolizumab in Combination with Flutamide Treatment for Advanced/Recurrence / Metastasis Head and Neck Squamous Cell Carcinoma: a Single-arm Clinical Study Trial",
"has_exemption": false,
"start_date": "2024-12-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Zhejiang Provincial People's Hospital",
"sponsor_slug": "zhejiang-provincial-peoples-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06668584",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06668584",
"title": "A Phase II Open-label Study of Olutasidenib Post-transplant Maintenance Therapy for Patients With IDH1-mutated Myeloid Malignancies",
"has_exemption": false,
"start_date": "2024-12-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06680869",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06680869",
"title": "Early Amiodarone in Shockable Cardiac Arrest (Early-Amio) Study",
"has_exemption": false,
"start_date": "2025-01-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Oregon Health and Science University",
"sponsor_slug": "oregon-health-and-science-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06824064",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06824064",
"title": "A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of RBS2418 Plus Best Supportive Care (BSC) in Subjects with Advanced, Metastatic, and Progressive Colorectal Cancer",
"has_exemption": false,
"start_date": "2025-01-17",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Riboscience, LLC.",
"sponsor_slug": "riboscience-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06138821",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06138821",
"title": "Effect of Endoscopic Sleeve Gastroplasty on Patients With Obesity and Concomitant Metabolic Dysfunction-Associated Steatohepatitis (MASH): A Multicenter, Open-label, Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2025-01-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Pichamol Jirapinyo, MD, MPH",
"sponsor_slug": "pichamol-jirapinyo-md-mph",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06764355",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06764355",
"title": "Total Neoadjuvant Therapy With Induction Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Locally Advanced Esophageal Squamous Cell Carcinoma",
"has_exemption": false,
"start_date": "2025-01-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Taiwan University Hospital",
"sponsor_slug": "national-taiwan-university-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06709014",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06709014",
"title": "A 6-month & 18-month Prospective, Randomized, Placebo-controlled, Double-blind Dual Clinical Trial Investigating Efficacy and Safety of Buntanetap in Treating Participants of Early Alzheimer's Disease",
"has_exemption": false,
"start_date": "2025-02-04",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Annovis Bio Inc.",
"sponsor_slug": "annovis-bio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06668571",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06668571",
"title": "Central and Peripheral GABA and Glutamate Modulation With Intravenous Ketamine for Treatment-Resistant Depression (G2K): A Randomized, Double-Blind, Placebo-Controlled Study",
"has_exemption": false,
"start_date": "2025-02-10",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06630728",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06630728",
"title": "Addiction Potential of Very Low Nicotine Filtered Little Cigars",
"has_exemption": false,
"start_date": "2025-02-13",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Ohio State University Comprehensive Cancer Center",
"sponsor_slug": "ohio-state-university-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06814938",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06814938",
"title": "A Novel Precision Medicine Approach for Obesity: a Randomized, Multi-Center Trial",
"has_exemption": false,
"start_date": "2025-02-21",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06849986",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06849986",
"title": "Tislelizumab Combined With Liposomal Doxorubicin and Ifosfamide as First-line Treatment for Patients With Specified Subtypes of Unresectable or Metastatic Soft Tissue Sarcoma: a Multi-center, Single-arm, Prospective Phase II Clinical Trial",
"has_exemption": false,
"start_date": "2025-02-25",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Fudan University",
"sponsor_slug": "fudan-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06843811",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06843811",
"title": "A Pilot Phase 2 Study With Long-Term Extension to Assess the Safety and Efficacy of Sirolimus in Patients With Leigh Syndrome Caused by Genetically-Confirmed Mitochondrial Respiratory Chain Deficiency",
"has_exemption": false,
"start_date": "2025-02-27",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Matthew Demczko",
"sponsor_slug": "matthew-demczko",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06328608",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06328608",
"title": "Multi-centre, Open-label Trial to Assess the saFety, Pharmacodynamics, Efficacy and Pharmacokinetics of pegunigaLsidase Alfa in Patients From 2 Years to Less Than 18 Years of Age With Confirmed FabrY Disease",
"has_exemption": false,
"start_date": "2025-02-28",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Chiesi Farmaceutici S.p.A.",
"sponsor_slug": "chiesi-farmaceutici-spa",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06673056",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06673056",
"title": "Effects of N-Acetyl-L-Leucine on Ataxia-Telangiectasia (A-T: A Phase III, Randomized, Placebo-controlled, Double-blind, Crossover Study",
"has_exemption": false,
"start_date": "2025-03-18",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "IntraBio Inc",
"sponsor_slug": "intrabio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06942520",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06942520",
"title": "A Randomized, Open Label, Controlled, Phase 2 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 AAV Gene Therapy Administered Via Subretinal Delivery in Participants With Center Involved Diabetic Macular Edema",
"has_exemption": false,
"start_date": "2025-03-18",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Sierra Eye Associates",
"sponsor_slug": "sierra-eye-associates",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06529835",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06529835",
"title": "A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair (NeuroSpan-1)",
"has_exemption": false,
"start_date": "2025-03-21",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Auxilium Biotechnologies",
"sponsor_slug": "auxilium-biotechnologies",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06803875",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06803875",
"title": "A Phase 1/2 Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma",
"has_exemption": false,
"start_date": "2025-03-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Roberto Chiarle",
"sponsor_slug": "roberto-chiarle",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06746623",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06746623",
"title": "Nonendoscopic Screening for Barrett's Esophagus and Esophageal Cancer in At-Risk Veterans Without History of Chronic Gastroesophageal Reflux",
"has_exemption": false,
"start_date": "2025-04-11",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Cleveland VA Medical Research and Education Foundation",
"sponsor_slug": "cleveland-va-medical-research-and-education-foundation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06364774",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06364774",
"title": "Phase 1/2 Study Evaluating the Safety and Efficacy of Gene Therapy Employing Lentiviral Vector ALS20-transduced Hematopoietic Progenitor Cells in Subjects With Transfusion-dependent-thalassemia",
"has_exemption": false,
"start_date": "2025-04-14",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Children's Hospital of Philadelphia",
"sponsor_slug": "childrens-hospital-of-philadelphia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06761404",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06761404",
"title": "Non-invasive VNS in Stroke Recovery",
"has_exemption": false,
"start_date": "2025-04-15",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "The Methodist Hospital Research Institute",
"sponsor_slug": "the-methodist-hospital-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06751602",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06751602",
"title": "A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Belumosudil for the Abrogation of Interstitial Fibrosis and Tubular Atrophy in de Novo Kidney Transplant Recipients",
"has_exemption": false,
"start_date": "2025-04-15",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "The Methodist Hospital Research Institute",
"sponsor_slug": "the-methodist-hospital-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06003166",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06003166",
"title": "Pharmaco-Diagnostic Crossover Trial for Peripheral Nerve Continuity After Trauma",
"has_exemption": false,
"start_date": "2025-04-21",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Arizona",
"sponsor_slug": "university-of-arizona",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05844501",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05844501",
"title": "Inhibition of Small Conductance Calcium-Activated Potassium Current: A New Therapeutic Approach for Atrial Fibrillation",
"has_exemption": false,
"start_date": "2025-04-22",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Indiana University",
"sponsor_slug": "indiana-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06526299",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06526299",
"title": "A Phase 2 Study of Biomarker-Modulated PSMA Theranostics",
"has_exemption": false,
"start_date": "2025-04-29",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Washington",
"sponsor_slug": "university-of-washington",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06834997",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06834997",
"title": "A Randomized, Double-Blind, Placebo-Controlled, Parallel Groups Study to Explore The Safety And Therapeutic Potential Of Cannabinoids As An Adjunct For Reducing Pain (Carp)- TCH",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Baylor College of Medicine",
"sponsor_slug": "baylor-college-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06955728",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06955728",
"title": "A Phase-IV Individually Randomized, Placebo-controlled Trial on Safety of RSVA/B-preF Vaccine in Pregnant Women and Efficacy Against Severe RSV-associated Lower Respiratory Tract Infection in Infants",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Witwatersrand, South Africa",
"sponsor_slug": "university-of-witwatersrand-south-africa",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06325696",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06325696",
"title": "Phase IIa Investigation of H01 in Adults With Interstitial Lung Disease (The SOLIS Study)",
"has_exemption": false,
"start_date": "2025-05-05",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Institute of Environmental Health Sciences (NIEHS)",
"sponsor_slug": "national-institute-of-environmental-health-sciences-niehs",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06875973",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06875973",
"title": "A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open-Label Pelacarsen in Participants With Elevated Lp(a) and Established ASCVD",
"has_exemption": false,
"start_date": "2025-05-20",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07039916",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07039916",
"title": "A Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Assess the Efficacy and Safety of IMVT-1402 in Patients With Mild to Severe Generalized Myasthenia Gravis",
"has_exemption": false,
"start_date": "2025-05-27",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Immunovant Sciences GmbH",
"sponsor_slug": "immunovant-sciences-gmbh",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06631638",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06631638",
"title": "Planned vs. Actual Acetabular Cup Position in Total Hip Arthroplasty With Non-Invasive Navigation",
"has_exemption": false,
"start_date": "2025-05-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "DePuy Orthopaedics",
"sponsor_slug": "depuy-orthopaedics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06911944",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06911944",
"title": "A Randomized, Double-Blind, Placebo-Controlled, Phase 4 Dose-Escalation Study Evaluating the Safety, Tolerability, and Efficacy of Donanemab in Adults With Down Syndrome",
"has_exemption": false,
"start_date": "2025-06-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Michael Rafii, MD, PhD",
"sponsor_slug": "michael-rafii-md-phd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07004192",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07004192",
"title": "The Role of hCG in Thawed Embryo Transfer",
"has_exemption": false,
"start_date": "2025-06-02",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Fertility Center of Las Vegas",
"sponsor_slug": "fertility-center-of-las-vegas",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06992258",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06992258",
"title": "A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Microsatellite Stable Colorectal Cancer",
"has_exemption": false,
"start_date": "2025-06-15",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Criterium, Inc.",
"sponsor_slug": "criterium-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06995898",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06995898",
"title": "The Vanguard Study: Testing a New Way to Screen for Cancer",
"has_exemption": false,
"start_date": "2025-06-16",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06630325",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06630325",
"title": "Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART): Adaptive Clinical Treatment (ACT)",
"has_exemption": false,
"start_date": "2025-06-24",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "OHSU Knight Cancer Institute",
"sponsor_slug": "ohsu-knight-cancer-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07009548",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07009548",
"title": "CytoGam® as Adjuvant Therapy to Prevent or Attenuate Human Cytomegalovirus (CMV) Infection and Disease in Solid Organ Transplant Recipients",
"has_exemption": false,
"start_date": "2025-06-26",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Fernanda P Silveira, MD, MS",
"sponsor_slug": "fernanda-p-silveira-md-ms",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06757634",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06757634",
"title": "VIKTORIA-2: A Randomized, Open-Label, Phase 3 Study of Fulvestrant and CDK4/6 Inhibitors With or Without Gedatolisib as First-Line Treatment in Patients With HR-Positive and HER2-Negative Advanced Breast Cancer",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Celcuity, Inc.",
"sponsor_slug": "celcuity-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06643260",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06643260",
"title": "A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Daily Piclidenoson (CF101) Administered Orally in Subjects With Moderate-to-Severe Plaque Psoriasis",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Can-Fite BioPharma",
"sponsor_slug": "can-fite-biopharma",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06499857",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06499857",
"title": "Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Chicago",
"sponsor_slug": "university-of-chicago",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06789302",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06789302",
"title": "A Double-Blind, Randomized, Placebo-Controlled Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of DT2-SCT in Subjects with Type 2 Diabetes Mellitus",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Global Institute of Stem Cell Therapy and Research",
"sponsor_slug": "global-institute-of-stem-cell-therapy-and-research",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06917313",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06917313",
"title": "A Randomized Phase II Study to Evaluate the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05199077",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05199077",
"title": "A Phase IIa Study to Investigate the Efficacy and Safety Profile of GM-XANTHO in Pressure Ulcer Patients",
"has_exemption": false,
"start_date": "2025-07-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Xantho Biotechnology Co., LTD",
"sponsor_slug": "xantho-biotechnology-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06622057",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06622057",
"title": "Phase III, Randomized, Double-blind Study of Combination Therapy With D07001-Softgel Capsules and Capecitabine vs Placebo and Capecitabine in Patients With Advanced BTC After Failed on Gemcitabine, Platin, and FOLFOX or Irinotecan Regimens",
"has_exemption": false,
"start_date": "2025-07-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "InnoPharmax Inc.",
"sponsor_slug": "innopharmax-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06999330",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06999330",
"title": "Parcel-guided Transcranial Magnetic Stimulation for Anxiety in Parkinson's Disease",
"has_exemption": false,
"start_date": "2025-07-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "HealthPartners Institute",
"sponsor_slug": "healthpartners-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06616584",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06616584",
"title": "A Randomized Phase II/III Study of Docetaxel and Ramucirumab With or Without Cemiplimab for Participants Previously Treated With Platinum-Based Chemotherapy and Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Non-Matched Sub-Study)",
"has_exemption": false,
"start_date": "2025-07-11",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "SWOG Cancer Research Network",
"sponsor_slug": "swog-cancer-research-network",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04645602",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04645602",
"title": "A Phase II Study of Lenvatinib in Combination With Pembrolizumab in HPV-associated Recurrent Respiratory Papillomatosis Patients",
"has_exemption": false,
"start_date": "2025-07-18",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06047015",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06047015",
"title": "Immune Response to Irreversible Electroporation (NanoKnife ®) and a Checkpoint Inhibitor With or Without CpG Oligodeoxynucleotides for the Treatment of Stage IV Colorectal Cancer",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Saskatchewan",
"sponsor_slug": "university-of-saskatchewan",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06876363",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06876363",
"title": "A Phase 1/2 Open-Label, Single-Ascending-Dose Study of EN-374, a Helper-Dependent Adenoviral-Based Gene Therapy, in Participants With X-Linked Chronic Granulomatous Disease",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Ensoma",
"sponsor_slug": "ensoma",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06904261",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06904261",
"title": "An Open-label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of 12 Month Treatment With Migalastat in Pediatric Subjects (Aged 2 to < 12 Years) With Fabry Disease and Amenable GLA Variants",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Amicus Therapeutics",
"sponsor_slug": "amicus-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07010159",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07010159",
"title": "A Phase 2/3 Efficacy and Safety Study of KPL-387 Treatment in Participants With Recurrent Pericarditis",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Kiniksa Pharmaceuticals International, plc",
"sponsor_slug": "kiniksa-pharmaceuticals-international-plc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05987007",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05987007",
"title": "Sleep Interventions and Neurocognitive Outcomes in Amnestic Mild Cognitive Impairment",
"has_exemption": false,
"start_date": "2025-08-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "New York State Psychiatric Institute",
"sponsor_slug": "new-york-state-psychiatric-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06559995",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06559995",
"title": "Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder",
"has_exemption": false,
"start_date": "2025-08-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Pennsylvania",
"sponsor_slug": "university-of-pennsylvania",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06294821",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06294821",
"title": "4-Aminopyridine to Delay Carpal Tunnel Release",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "John Elfar",
"sponsor_slug": "john-elfar",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06449313",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06449313",
"title": "A Phase 2 Single-Arm Study of Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advance Non-Small Cell Lung Cancer (NSCLC) With N3 Lymph Node Involvement",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Georgetown University",
"sponsor_slug": "georgetown-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06708754",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06708754",
"title": "PBM-LEF Study: The Impact of PBM on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients: A Feasibility Study",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "NYU Langone Health",
"sponsor_slug": "nyu-langone-health",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06623240",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06623240",
"title": "A Randomized, Double-Blind, Phase 2, Efficacy and Safety Cross-Over Study of Allogeneic HB-adMSCs vs Placebo for the Treatment of Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Hope Biosciences",
"sponsor_slug": "hope-biosciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06948214",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06948214",
"title": "A Multicenter, 12-Month, Randomized, Double Blind, Placebo-Controlled Phase 3 Efficacy and Safety Study of Daily Oral LUM-201 in Naïve-to-Treatment, Prepubertal Children With Growth Hormone Deficiency (GHD)",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Lumos Pharma",
"sponsor_slug": "lumos-pharma",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07017673",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07017673",
"title": "Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early Stage Triple Negative Breast Cancer",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Cedars-Sinai Medical Center",
"sponsor_slug": "cedars-sinai-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07019610",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07019610",
"title": "Evaluation of Chlorhexidine Caps for Central Line Associated Blood Stream Infection Prevention in People Needing Hemodialysis: a Pilot Randomised Control Trial",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "The University of Queensland",
"sponsor_slug": "the-university-of-queensland",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07039526",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07039526",
"title": "Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "John Waters",
"sponsor_slug": "john-waters",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07094906",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07094906",
"title": "Neural and Vascular Modulation With Isometric Handgrip Training in Chronic Kidney Disease",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Emory University",
"sponsor_slug": "emory-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06528769",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06528769",
"title": "A Phase II Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma",
"has_exemption": false,
"start_date": "2025-09-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Gabriel Tinoco",
"sponsor_slug": "gabriel-tinoco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06738368",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06738368",
"title": "Dose-Adjusted Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) ± Rituximab + Recombinant Erwinia Asparaginase (JZP458; Rylaze®) for the Treatment of Newly-Diagnosed Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Lymphoma/Leukemia",
"has_exemption": false,
"start_date": "2025-09-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Washington",
"sponsor_slug": "university-of-washington",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04589065",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04589065",
"title": "Pilot Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device (SCD) to Treat Patients With NYHA Stage III or IV Heart Failure (HF) With Persistent Congestion and Worsening Renal Function as a Result of Cardiorenal Syndrome (CRS) That is Resistant to Optimal Medical Therapy Including Loop Diuretics",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Lenar Yessayan",
"sponsor_slug": "lenar-yessayan",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06040476",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06040476",
"title": "A Phase II, Randomized, Double-blind, Parallel, Placebo-controlled Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood Infusion in Patients with Acute Ischemic Stroke",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "StemCyte, Inc.",
"sponsor_slug": "stemcyte-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06294574",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06294574",
"title": "Improved Successful Retrieval Rate of HydroMARK Plus Breast Biopsy Site Marker in Comparison to HydroMARK as Well as Improved Surgeon Satisfaction",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06666608",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06666608",
"title": "The Efficacy of Bone Stimulator in Treatment and Return-to-Sport for Spondylolysis",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "The Methodist Hospital Research Institute",
"sponsor_slug": "the-methodist-hospital-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06863311",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06863311",
"title": "EXACT: Randomized Phase II Trial of XL092 in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Karie Runcie",
"sponsor_slug": "karie-runcie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06907654",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06907654",
"title": "Couples' Affect in Relationships Study",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Wisconsin, Madison",
"sponsor_slug": "university-of-wisconsin-madison",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07077746",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07077746",
"title": "A Randomized, Double-Blind, Phase 2, Efficacy and Safety Study of Allogeneic HB-adMSCs vs Placebo for the Treatment of Crohn's Disease",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Hope Biosciences",
"sponsor_slug": "hope-biosciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07092527",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07092527",
"title": "Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Diego",
"sponsor_slug": "university-of-california-san-diego",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06620692",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06620692",
"title": "A Phase IIa Study to Investigate the Efficacy and Safety Profile of GM-XANTHO [GM-XAN003] in Patients with Psoriasis",
"has_exemption": false,
"start_date": "2025-10-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Xantho Biotechnology Co., LTD",
"sponsor_slug": "xantho-biotechnology-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06116838",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06116838",
"title": "Effect of Varying Transcutaneous Spinal Cord Stimulation Parameters and Location on Lower Extremity Motor Responses and Comfort",
"has_exemption": false,
"start_date": "2025-10-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Shirley Ryan AbilityLab",
"sponsor_slug": "shirley-ryan-abilitylab",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06820281",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06820281",
"title": "Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes: a Phase 2 Double Blinded Placebo Controlled Clinical Trial (TIRTLE2)",
"has_exemption": false,
"start_date": "2025-12-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Garvan Institute of Medical Research",
"sponsor_slug": "garvan-institute-of-medical-research",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06950281",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06950281",
"title": "Low Sodium Oxybate Use for Nocturnal Cluster Headache: Safety, Efficacy and Tolerability of JZP-258 (XYWAV) - a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Bi-center Study.",
"has_exemption": false,
"start_date": "2025-12-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Leiden University Medical Center",
"sponsor_slug": "leiden-university-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07057791",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07057791",
"title": "Phase II Dose Optimization Study of Platinum/Etoposide Plus Ivonescimab (CEI) as First-Line Treatment of Extensive-Stage Small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2025-12-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "PrECOG, LLC.",
"sponsor_slug": "precog-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02944955",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02944955",
"title": "A Study of BLEX 404 Oral Liquid in Patients With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-Risk Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML)",
"has_exemption": false,
"start_date": "2026-01-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "BioLite, Inc.",
"sponsor_slug": "biolite-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05764928",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05764928",
"title": "A Phase I/II, Open Label Study to Evaluate the Safety and Efficacy of BLEX 404Oral Liquid Combined With Pemetrexed + Cisplatin Therapy in Patients With Advanced Inoperable or Metastatic EGFR Wild-type Non-Small Cell Lung Cancer Patients",
"has_exemption": false,
"start_date": "2026-01-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Rgene Corporation",
"sponsor_slug": "rgene-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06895889",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06895889",
"title": "A Prospective, Randomized, Controlled, Open-label, First-in-human Phase I/IIb Study to Evaluate the Safety and Efficacy of the EB-OC Graft in the Repair of Full Thickness Chondral/osteochondral Defects of the Knee",
"has_exemption": false,
"start_date": "2026-01-01",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Epibone, Inc.",
"sponsor_slug": "epibone-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06661915",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06661915",
"title": "A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs)",
"has_exemption": false,
"start_date": "2026-02-03",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05423197",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05423197",
"title": "Phase II Study Evaluating Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in Head and Neck Squamous Cell Carcinoma",
"has_exemption": false,
"start_date": "2026-06-30",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05039892",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05039892",
"title": "An Open-label, Single Arm, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of 3D185 Monotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Cholangiocarcinoma With FGFR2 Gene Alterations",
"has_exemption": false,
"start_date": "2026-12-31",
"completion_date": "2027-12-31",
"has_results": false,
"results_due": false,
"sponsor_name": "3D Medicines (Beijing) Co., Ltd.",
"sponsor_slug": "3d-medicines-beijing-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02407405",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02407405",
"title": "Phase II Trial of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas",
"has_exemption": false,
"start_date": "2016-01-07",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT03475147",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03475147",
"title": "Validation of a Smartphone-Based Flicker Fusion Test",
"has_exemption": false,
"start_date": "2017-01-27",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Randy Kardon",
"sponsor_slug": "randy-kardon",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03475173",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03475173",
"title": "New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation",
"has_exemption": false,
"start_date": "2019-05-06",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Randy Kardon",
"sponsor_slug": "randy-kardon",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03694626",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03694626",
"title": "Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity",
"has_exemption": false,
"start_date": "2019-07-11",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Randy Kardon",
"sponsor_slug": "randy-kardon",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03952637",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03952637",
"title": "A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis",
"has_exemption": false,
"start_date": "2019-08-19",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "National Human Genome Research Institute (NHGRI)",
"sponsor_slug": "national-human-genome-research-institute-nhgri",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04267887",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04267887",
"title": "Advanced ChemoHormonal Therapy for Treatment Naïve Metastatic Prostate Cancer: Apalutamide and Abiraterone Acetate With Prednisone and Androgen Deprivation Therapy After Treatment With Docetaxel and Androgen Deprivation Therapy",
"has_exemption": false,
"start_date": "2020-05-11",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "OHSU Knight Cancer Institute",
"sponsor_slug": "ohsu-knight-cancer-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05504499",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05504499",
"title": "REFINE Study: A Prospective, Observational, Open-Label, Non-Randomized, Multi-Center Study Measuring Functional Outcomes In a Novel Interspinous Fusion Device In Subjects With Low Back Pain",
"has_exemption": false,
"start_date": "2021-03-19",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Pacific Research Institute",
"sponsor_slug": "pacific-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03496883",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03496883",
"title": "Recombinant Factor VIIa (rFVIIa) for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial",
"has_exemption": false,
"start_date": "2021-12-03",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Joseph Broderick, MD",
"sponsor_slug": "joseph-broderick-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05332067",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05332067",
"title": "Omalizumab Before Onset of Exacerbations",
"has_exemption": false,
"start_date": "2022-05-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Children's National Research Institute",
"sponsor_slug": "childrens-national-research-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05537402",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05537402",
"title": "Phase II Multi-center Randomized, Open-label, Trial of Atezolizumab and Bevacizumab vs Locoregional Therapy (Transarterial Chemoembozliation or Radioembolization) as First-line Therapy in Patients With Large Intermediate-stage Hepatocellular Carcinoma",
"has_exemption": false,
"start_date": "2023-09-27",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas Southwestern Medical Center",
"sponsor_slug": "university-of-texas-southwestern-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06185816",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06185816",
"title": "Non-Invasive Pulsed Radiofrequency for the Treatment of Neuropathic Pain",
"has_exemption": false,
"start_date": "2024-01-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06176261",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06176261",
"title": "DATO-BASE: A Phase 2 Trial of DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs",
"has_exemption": false,
"start_date": "2024-01-08",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Sarah Sammons, MD",
"sponsor_slug": "sarah-sammons-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06845735",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06845735",
"title": "Prospective Randomized Control Trial Comparing Absorbable Sutures to Non-Absorbable Sutures for Capsular Closures in Hip Arthroscopies",
"has_exemption": false,
"start_date": "2024-03-22",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Missouri-Columbia",
"sponsor_slug": "university-of-missouri-columbia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05947500",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05947500",
"title": "A Randomized Phase 2 Study of ATR Inhibition in Advanced PD-(L)1-Refractory Merkel Cell Carcinoma: The MATRiX Trial",
"has_exemption": false,
"start_date": "2024-05-21",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06059391",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06059391",
"title": "Placebo-Controlled and Randomized Phase 2 Trial of CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors to Enhance CMV-Specific Immunity and Prevent CMV Viremia in Recipients After Hematopoietic Stem Cell Transplant",
"has_exemption": false,
"start_date": "2024-07-12",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06533826",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06533826",
"title": "A Phase II Non-comparative Trial of Datopotamab Deruxtecan (Dato-DXd) or Trastuzumab Deruxtecan (T-DXd) in Patients With Metastatic HER2-negative (HER2-low or HER2-0) Breast Cancer After Progression on Prior Antibody Drug Conjugate Therapy",
"has_exemption": false,
"start_date": "2024-10-29",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Ana C Garrido-Castro, MD",
"sponsor_slug": "ana-c-garrido-castro-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06973512",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06973512",
"title": "HABITS Study (Helping Addiction by Individualized Therapeutic Stimulation): Pilot Trial of Deep Brain Stimulation Guided By Stereoelectroencephalography for Treatment-Refractory Substance Use Disorders",
"has_exemption": false,
"start_date": "2024-11-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Centre for Addiction and Mental Health",
"sponsor_slug": "centre-for-addiction-and-mental-health",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06741969",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06741969",
"title": "A Randomized, Placebo-controlled, Double-blind, Multicenter Phase 3 Protocol to Assess the Efficacy and Safety of Nipocalimab in Adults With Moderate to Severe Sjogren's Disease (SjD)",
"has_exemption": false,
"start_date": "2024-12-04",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06741579",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06741579",
"title": "Mechanisms of Stimulation for Pain Alleviation",
"has_exemption": false,
"start_date": "2025-01-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06627673",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06627673",
"title": "MultiCenter Prospective Parallel Registry Controlled Investigational Device Exemption Clinical Study to Determine Non-Inferiority of the PEEK-OPTIMA™ Femoral Component Versus a CoCr Alloy Femoral Component of Similar Design for TKA",
"has_exemption": false,
"start_date": "2025-01-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Maxx Orthopedics Inc",
"sponsor_slug": "maxx-orthopedics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06286397",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06286397",
"title": "Topical Anti-Androgens in Pilonidal Sinus Disease",
"has_exemption": false,
"start_date": "2025-01-10",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Pennsylvania",
"sponsor_slug": "university-of-pennsylvania",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06355310",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06355310",
"title": "Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease",
"has_exemption": false,
"start_date": "2025-01-27",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Ann & Robert H Lurie Children's Hospital of Chicago",
"sponsor_slug": "ann-robert-h-lurie-childrens-hospital-of-chicago",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06771622",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06771622",
"title": "Phase Ib/IIa, Open-label, Multicenter, Dose Escalation, and Dose Expansion Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of HCB101 in Combination With Multiple Agents in Subjects With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2025-03-13",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "FBD Biologics Limited",
"sponsor_slug": "fbd-biologics-limited",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06753916",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06753916",
"title": "Multicenter Clinical Trial to Evaluate the Safety and Efficacy of Ex Vivo Corneal Cross-linking of Donor Corneal Tissue Used for Vascularized High-risk Keratoplasty",
"has_exemption": false,
"start_date": "2025-04-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts Eye and Ear Infirmary",
"sponsor_slug": "massachusetts-eye-and-ear-infirmary",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03867487",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03867487",
"title": "SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Ann & Robert H Lurie Children's Hospital of Chicago",
"sponsor_slug": "ann-robert-h-lurie-childrens-hospital-of-chicago",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06885554",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06885554",
"title": "Adjustment Disorders in the US Military: Disease Trajectories and ADNM-20-Mil Validation",
"has_exemption": false,
"start_date": "2025-06-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Henry M. Jackson Foundation for the Advancement of Military Medicine",
"sponsor_slug": "henry-m-jackson-foundation-for-the-advancement-of-military-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06630221",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06630221",
"title": "A Phase II Study of Eltrombopag as a Novel Therapeutic Approach for Patients With Low-risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) With TET2 Mutations",
"has_exemption": false,
"start_date": "2025-06-17",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Abhay Singh, MD MPH",
"sponsor_slug": "abhay-singh-md-mph",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06868381",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06868381",
"title": "A Phase IIa, Single-Site, Open-Label Trial of Baricitinib in Patients With Cardiac Sarcoidosis",
"has_exemption": false,
"start_date": "2025-07-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06554717",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06554717",
"title": "Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV",
"has_exemption": false,
"start_date": "2025-07-07",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06901687",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06901687",
"title": "Home-Based tDCS for Depression in Multiple Sclerosis: A Randomized Sham-Controlled Trial",
"has_exemption": false,
"start_date": "2025-07-21",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "NYU Langone Health",
"sponsor_slug": "nyu-langone-health",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06707493",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06707493",
"title": "A Randomized, Placebo-Controlled Phase 2 Study of IDH1 Inhibition Using Ivosidenib as Maintenance Therapy for IDH1-mutant Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation",
"has_exemption": false,
"start_date": "2025-08-10",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Massachusetts General Hospital",
"sponsor_slug": "massachusetts-general-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06654193",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06654193",
"title": "Allogeneic Adipose-derived Mesenchymal Stem Cells (MSC) for Acute Kidney Injury After Trauma or Burn",
"has_exemption": false,
"start_date": "2025-09-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Hope Biosciences",
"sponsor_slug": "hope-biosciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07049848",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07049848",
"title": "SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma",
"has_exemption": false,
"start_date": "2025-12-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05194332",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05194332",
"title": "Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function",
"has_exemption": false,
"start_date": "2026-01-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "The University of Texas Health Science Center, Houston",
"sponsor_slug": "the-university-of-texas-health-science-center-houston",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07017634",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07017634",
"title": "Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease : A Pivotal, Randomized, Prospective, Multi-Center Study",
"has_exemption": false,
"start_date": "2026-01-01",
"completion_date": "2028-01-01",
"has_results": false,
"results_due": false,
"sponsor_name": "CGBio Inc.",
"sponsor_slug": "cgbio-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06183268",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06183268",
"title": "Evaluation of Radiobiological Effects in Skin Toxicities for Head and Neck Cancer Patients With Pencil Beam Scanning Proton Therapy",
"has_exemption": false,
"start_date": "2023-12-13",
"completion_date": "2028-01-02",
"has_results": false,
"results_due": false,
"sponsor_name": "Thompson Cancer Survival Center",
"sponsor_slug": "thompson-cancer-survival-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07063212",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07063212",
"title": "A Phase II Study of Sacituzumab Govitecan in Combination With Cetuximab in Patients With Recurrent Metastatic HNSCC That Has Progressed After First-Line Therapy",
"has_exemption": false,
"start_date": "2025-07-02",
"completion_date": "2028-01-02",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06451757",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06451757",
"title": "A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant",
"has_exemption": false,
"start_date": "2025-08-02",
"completion_date": "2028-01-02",
"has_results": false,
"results_due": false,
"sponsor_name": "Khondrion BV",
"sponsor_slug": "khondrion-bv",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07015242",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07015242",
"title": "The CAROLYN Trial: Lisocabtagene Maraleucelas First-Line Therapy for Primary Central Nervous System Lymphoma (PCNSL) in Transplant-Ineligible Patients",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2028-01-02",
"has_results": false,
"results_due": false,
"sponsor_name": "Juno Therapeutics, Inc., a Bristol-Myers Squibb Company",
"sponsor_slug": "juno-therapeutics-inc-a-bristol-myers-squibb-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06732388",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06732388",
"title": "Repurposing Itraconazole for Secondary Prevention of Metaplasia and Primary Prevention of Cancer in Patients With High-Risk Barrett's Esophagus in Combination With Ablation",
"has_exemption": false,
"start_date": "2025-10-01",
"completion_date": "2028-01-02",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03625648",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03625648",
"title": "CSP #2008 - Pentoxifylline in Diabetic Kidney Disease",
"has_exemption": false,
"start_date": "2019-11-18",
"completion_date": "2028-01-03",
"has_results": false,
"results_due": false,
"sponsor_name": "VA Office of Research and Development",
"sponsor_slug": "va-office-of-research-and-development",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06891417",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06891417",
"title": "A Phase 1/2, Randomized, Placebo-controlled, Multi-arm, Dose-finding Study to Evaluate the Safety, Immunogenicity, and Efficacy of a Chlamydia Trachomatis mRNA Vaccine Candidate in Adults Aged 18 to 29 Years",
"has_exemption": false,
"start_date": "2025-03-27",
"completion_date": "2028-01-03",
"has_results": false,
"results_due": false,
"sponsor_name": "Sanofi",
"sponsor_slug": "sanofi",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05733000",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05733000",
"title": "Phase II Open-Label Multi-Cohort Study Evaluating CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Patients With Advanced Chemorefractory Colorectal, Pancreatic, or Other Solid Cancers",
"has_exemption": false,
"start_date": "2023-03-08",
"completion_date": "2028-01-04",
"has_results": false,
"results_due": false,
"sponsor_name": "Northwestern University",
"sponsor_slug": "northwestern-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05797168",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05797168",
"title": "A Modular Phase I/IIa, Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Ascending Doses of AZD5335 Monotherapy and in Combination With Anti-cancer Agents in Participants With Solid Tumors",
"has_exemption": false,
"start_date": "2023-06-05",
"completion_date": "2028-01-06",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06268873",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06268873",
"title": "A Phase III, Randomised, Double-Blind Study to Assess the Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Chronic Kidney Disease (CKD) Progression in Participants With CKD and High Blood Pressure",
"has_exemption": false,
"start_date": "2024-03-29",
"completion_date": "2028-01-07",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06731894",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06731894",
"title": "A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy",
"has_exemption": false,
"start_date": "2025-10-27",
"completion_date": "2028-01-07",
"has_results": false,
"results_due": false,
"sponsor_name": "City of Hope Medical Center",
"sponsor_slug": "city-of-hope-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06307431",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06307431",
"title": "A Phase 2, Randomized, Double-blind, Clinical Study of V940 (mRNA-4157) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in the Adjuvant Treatment of Participants With Renal Cell Carcinoma (INTerpath-004).",
"has_exemption": false,
"start_date": "2024-04-10",
"completion_date": "2028-01-08",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04083183",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04083183",
"title": "Targeted Astatine-211-Labeled BC8-B10 Monoclonal Antibody as Reduced Intensity Conditioning for Nonmalignant Diseases",
"has_exemption": false,
"start_date": "2020-06-16",
"completion_date": "2028-01-09",
"has_results": false,
"results_due": false,
"sponsor_name": "Fred Hutchinson Cancer Center",
"sponsor_slug": "fred-hutchinson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06132958",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06132958",
"title": "A Phase 3, Randomized, Active-controlled, Open-label, Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician's Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy (MK-2870-005/ENGOT-en23/GOG-3095)",
"has_exemption": false,
"start_date": "2023-12-06",
"completion_date": "2028-01-10",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06223568",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06223568",
"title": "Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer",
"has_exemption": false,
"start_date": "2024-06-10",
"completion_date": "2028-01-10",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06433219",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06433219",
"title": "An Open-label, Multicenter, Randomized Phase 2 Study of the ATR Inhibitor Tuvusertib in Combination With the PARP Inhibitor Niraparib or the ATM Inhibitor Lartesertib in Participants With BRCA Mutant and/or Homologous Recombination deficiency (HRD)-Positive Epithelial Ovarian Cancer That Progressed on Prior PARP Inhibitor Therapy (DDRiver EOC 302)",
"has_exemption": false,
"start_date": "2024-10-30",
"completion_date": "2028-01-10",
"has_results": false,
"results_due": false,
"sponsor_name": "EMD Serono Research & Development Institute, Inc.",
"sponsor_slug": "emd-serono-research-development-institute-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06120491",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06120491",
"title": "A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)",
"has_exemption": false,
"start_date": "2023-11-21",
"completion_date": "2028-01-11",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07071623",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07071623",
"title": "A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of MK-8527 Oral Once-Monthly as HIV-1 Preexposure Prophylaxis in Women",
"has_exemption": false,
"start_date": "2025-10-31",
"completion_date": "2028-01-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03476681",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03476681",
"title": "Phase 1/2 With Expansion Cohorts in a Study of NEO-201 in Adults With Chemo-Resistant Solid Tumors",
"has_exemption": false,
"start_date": "2019-01-18",
"completion_date": "2028-01-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Precision Biologics, Inc",
"sponsor_slug": "precision-biologics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05668351",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05668351",
"title": "Phase II Trial Of Sparing The Urethra, Pudendal Artery And Rectum During Stereotactic Ablative Body Radiotherapy (SUPR-SABR) for Low and Intermediate Risk Prostate Cancer",
"has_exemption": false,
"start_date": "2023-05-12",
"completion_date": "2028-01-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Medical University of South Carolina",
"sponsor_slug": "medical-university-of-south-carolina",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06043674",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06043674",
"title": "A Phase 2 Study of Glofitamab as Monotherapy or in Combination With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation",
"has_exemption": false,
"start_date": "2024-01-22",
"completion_date": "2028-01-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Christine Ryan",
"sponsor_slug": "christine-ryan",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06194929",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06194929",
"title": "Phase 1b/2 Trial of Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma",
"has_exemption": false,
"start_date": "2024-03-07",
"completion_date": "2028-01-15",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Utah",
"sponsor_slug": "university-of-utah",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02912559",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02912559",
"title": "Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair",
"has_exemption": false,
"start_date": "2017-10-16",
"completion_date": "2028-01-17",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07079735",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07079735",
"title": "VALganciclovir vs. LETermovir for Primary Prevention of CMV in Moderate to High-Risk Heart Transplant Recipients (The VALET-CMV Study)",
"has_exemption": false,
"start_date": "2025-08-17",
"completion_date": "2028-01-17",
"has_results": false,
"results_due": false,
"sponsor_name": "Columbia University",
"sponsor_slug": "columbia-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05038150",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05038150",
"title": "Phase I/IIa, Open-label Study to Evaluate Safety, Tolerability and Preliminary Efficacy of Modified Salmonella Typhimurium SGN1 in Patients With Advanced Solid Tumor",
"has_exemption": false,
"start_date": "2023-01-16",
"completion_date": "2028-01-18",
"has_results": false,
"results_due": false,
"sponsor_name": "Guangzhou Sinogen Pharmaceutical Co., Ltd",
"sponsor_slug": "guangzhou-sinogen-pharmaceutical-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06940518",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06940518",
"title": "Phase II Trial of Ivonescimab in Previously Treated Patients With Advanced Clear Cell Renal Cell Carcinoma",
"has_exemption": false,
"start_date": "2025-10-09",
"completion_date": "2028-01-19",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06599502",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06599502",
"title": "A Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0022 Monotherapy and in Combination With Anti-cancer Agents in Participants With Tumours Harbouring a KRASG12D Mutation (ALAFOSS-01)",
"has_exemption": false,
"start_date": "2024-10-18",
"completion_date": "2028-01-20",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06798324",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06798324",
"title": "Using Non-Invasive Brain Stimulation (tDCS) as an Adjunct to Varenicline for the Treatment of Tobacco Dependence: a Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2025-03-01",
"completion_date": "2028-01-20",
"has_results": false,
"results_due": false,
"sponsor_name": "Centre for Addiction and Mental Health",
"sponsor_slug": "centre-for-addiction-and-mental-health",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06831136",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06831136",
"title": "Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma; a Phase II Trial PANcreas CAncer RaDIofrequeNcy AbLation",
"has_exemption": false,
"start_date": "2025-03-26",
"completion_date": "2028-01-20",
"has_results": false,
"results_due": false,
"sponsor_name": "The University of Texas Health Science Center, Houston",
"sponsor_slug": "the-university-of-texas-health-science-center-houston",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06421636",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06421636",
"title": "A PHASE 2, TWO-PART, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF SUBCUTANEOUSLY ADMINISTERED REGN7999 (AN INHIBITOR OF TMPRSS6) IN PARTICIPANTS WITH IRON OVERLOAD DUE TO NON-TRANSFUSION DEPENDENT β-THALASSEMIA",
"has_exemption": false,
"start_date": "2024-09-30",
"completion_date": "2028-01-24",
"has_results": false,
"results_due": false,
"sponsor_name": "Regeneron Pharmaceuticals",
"sponsor_slug": "regeneron-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06170788",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06170788",
"title": "A Randomized, Open-label, Phase 3 Study of MK-2870 in Combination With Pembrolizumab Compared to Pembrolizumab Monotherapy in the First-line Treatment of Participants With Metastatic Non-small Cell Lung Cancer With PD-L1 TPS Greater Than or Equal to 50% (TroFuse-007)",
"has_exemption": false,
"start_date": "2023-12-15",
"completion_date": "2028-01-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06906211",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06906211",
"title": "Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula",
"has_exemption": false,
"start_date": "2025-01-15",
"completion_date": "2028-01-26",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington D.C. Veterans Affairs Medical Center",
"sponsor_slug": "washington-dc-veterans-affairs-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06710132",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06710132",
"title": "PROCEADE PanTumor: A Phase 1b/2, Multicenter, Open-Label Study of Anti-CEACAM5 Antibody-Drug Conjugate M9140 in Participants With Advanced Solid Tumors (Master Protocol)",
"has_exemption": false,
"start_date": "2025-01-29",
"completion_date": "2028-01-26",
"has_results": false,
"results_due": false,
"sponsor_name": "EMD Serono Research & Development Institute, Inc.",
"sponsor_slug": "emd-serono-research-development-institute-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05902169",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05902169",
"title": "A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.",
"has_exemption": false,
"start_date": "2024-01-29",
"completion_date": "2028-01-28",
"has_results": false,
"results_due": false,
"sponsor_name": "CarThera",
"sponsor_slug": "carthera",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06544291",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06544291",
"title": "Combination of THC and CBD as Novel Treatment for Co-Occurring Opioid Use Disorder and Chronic Pain",
"has_exemption": false,
"start_date": "2024-10-22",
"completion_date": "2028-01-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06818643",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06818643",
"title": "A Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2025-03-25",
"completion_date": "2028-01-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Merck Sharp & Dohme LLC",
"sponsor_slug": "merck-sharp-dohme-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06830798",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06830798",
"title": "A Phase 3, Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation",
"has_exemption": false,
"start_date": "2025-05-19",
"completion_date": "2028-01-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Alexion Pharmaceuticals, Inc.",
"sponsor_slug": "alexion-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06790693",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06790693",
"title": "A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Inavolisib Plus a CDK4/6 Inhibitor and Letrozole Versus Placebo Plus a CDK4/6 Inhibitor and Letrozole in Patients With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer",
"has_exemption": false,
"start_date": "2025-04-09",
"completion_date": "2028-01-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06138977",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06138977",
"title": "Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs",
"has_exemption": false,
"start_date": "2023-12-06",
"completion_date": "2028-01-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Michigan",
"sponsor_slug": "university-of-michigan",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05421858",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05421858",
"title": "An Interventional Efficacy and Safety Phase 3 Double-blind 2-arm Study to Investigate IV Followed by Oral Fosmanogepix Compared With IV Caspofungin Followed by Oral Fluconazole in Adult Participants With Candidemia and/or Invasive Candidiasis",
"has_exemption": false,
"start_date": "2024-12-11",
"completion_date": "2028-01-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Basilea Pharmaceutica",
"sponsor_slug": "basilea-pharmaceutica",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06157151",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06157151",
"title": "A Randomized, Open-label, Two-arm, Multicenter Phase 2 Study to Evaluate Efficacy and Safety of PRGN-2009 in Combination With Pembrolizumab Versus Pembrolizumab Monotherapy in Patients With Recurrent or Metastatic Cervical Cancer.",
"has_exemption": false,
"start_date": "2025-03-21",
"completion_date": "2028-01-30",
"has_results": false,
"results_due": false,
"sponsor_name": "Precigen, Inc",
"sponsor_slug": "precigen-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06294548",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06294548",
"title": "A Phase Ib/II, Dose Escalation and Dose Expansion Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in Advanced Hepatocellular Carcinoma (HCC)",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2028-01-30",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Alabama at Birmingham",
"sponsor_slug": "university-of-alabama-at-birmingham",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02140255",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02140255",
"title": "Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission: A Phase I/II Proof of Concept Study",
"has_exemption": false,
"start_date": "2015-01-23",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Institute of Allergy and Infectious Diseases (NIAID)",
"sponsor_slug": "national-institute-of-allergy-and-infectious-diseases-niaid",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT02649959",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02649959",
"title": "An Open-Label Extension Study of CM-AT for the Treatment of Children With Autism With All Levels of Fecal Chymotrypsin",
"has_exemption": false,
"start_date": "2015-10-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Curemark",
"sponsor_slug": "curemark",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT04242602",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04242602",
"title": "Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury",
"has_exemption": false,
"start_date": "2018-11-06",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Texas Southwestern Medical Center",
"sponsor_slug": "university-of-texas-southwestern-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02570984",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02570984",
"title": "Controlling and Preventing Asthma Progression and Severity in Kids",
"has_exemption": false,
"start_date": "2018-11-27",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Boston Children’s Hospital",
"sponsor_slug": "boston-childrens-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03900429",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03900429",
"title": "A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (Resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation",
"has_exemption": true,
"start_date": "2019-03-28",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Madrigal Pharmaceuticals, Inc.",
"sponsor_slug": "madrigal-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04136353",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04136353",
"title": "DASL-HiCaP: Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (ANZUP1801): A Randomised Phase 3 Double-blind, Placebo-controlled Trial of Adding Darolutamide to Androgen Deprivation Therapy and Definitive or Salvage Radiation in Very High Risk, Clinically Localised Prostate Cancer",
"has_exemption": false,
"start_date": "2020-03-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Sydney",
"sponsor_slug": "university-of-sydney",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04396574",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04396574",
"title": "A Phase 3, 12-Month, Open-Label Study of Lasmiditan in Pediatric Patients With Migraine - PIONEER-PEDS2",
"has_exemption": false,
"start_date": "2020-06-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Eli Lilly and Company",
"sponsor_slug": "eli-lilly-and-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04414475",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04414475",
"title": "A Phase 2b, Open-label, Multi-arm Clinical Trial of Selinexor Plus Low-dose Dexamethasone (Sd) in Patients with Penta-refractory Multiple Myeloma or Selinexor and Bortezomib Plus Low-dose Dexamethasone (SVd) in Patients with Triple-class Refractory Multiple Myeloma",
"has_exemption": false,
"start_date": "2020-07-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Karyopharm Therapeutics Inc",
"sponsor_slug": "karyopharm-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04643366",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04643366",
"title": "Phase 2 Study of Total Neoadjuvant mFOLFOX and Short-Course Radiotherapy in Resectable Rectal Cancer",
"has_exemption": false,
"start_date": "2021-01-28",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Virginia Commonwealth University",
"sponsor_slug": "virginia-commonwealth-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04457596",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04457596",
"title": "The CompassHER2 Trials (Comprehensive Use of Pathologic Response Assessment to Optimize Therapy in HER2-Positive Breast Cancer) CompassHER2 Residual Disease (RD), a Double-Blinded, Phase III Randomized Trial of T-DM1 Compared with T-DM1 and Tucatinib",
"has_exemption": false,
"start_date": "2021-03-02",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Alliance for Clinical Trials in Oncology",
"sponsor_slug": "alliance-for-clinical-trials-in-oncology",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04667585",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04667585",
"title": "Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx Using Metabolic Signature From Interim 18FDG-PET/CT",
"has_exemption": false,
"start_date": "2021-04-12",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Duke University",
"sponsor_slug": "duke-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04685590",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04685590",
"title": "Phase II Clinical Trial to Evaluate the Safety and Feasibility of Senolytic Therapy in Alzheimer's Disease",
"has_exemption": false,
"start_date": "2021-12-22",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05127954",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05127954",
"title": "A Multicenter, Open-label, Extension Study to Evaluate the Long-term Safety and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17)",
"has_exemption": false,
"start_date": "2022-01-14",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05130177",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05130177",
"title": "Phase II Study of PD-1 Inhibitor Zimberelimab (AB122) With TIGIT Inhibitor Domvanalimab (AB154) in PD-1 Relapsed/Refractory Melanoma",
"has_exemption": false,
"start_date": "2022-03-16",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Diwakar Davar",
"sponsor_slug": "diwakar-davar",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04105270",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04105270",
"title": "A Randomized Double Blind Phase II Trial of Restorative Microbiota Therapy (RMT) in Combination With Durvalumab (MEDI4736) and Chemotherapy in Untreated Patients With Advanced or Metastatic Adenocarcinoma Non-Small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2022-11-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Masonic Cancer Center, University of Minnesota",
"sponsor_slug": "masonic-cancer-center-university-of-minnesota",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05452564",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05452564",
"title": "Phase II Study to Evaluate the Efficacy and Safety of Baricitinib for Reduction of HIV in the Central Nervous System",
"has_exemption": false,
"start_date": "2023-05-18",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "William Tyor",
"sponsor_slug": "william-tyor",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05867251",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05867251",
"title": "A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-021 as a Single Agent and in Combination Therapy in Patients With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2023-08-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Avenzo Therapeutics, Inc.",
"sponsor_slug": "avenzo-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06012240",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06012240",
"title": "A Phase 3 Randomized, Placebo-controlled, Double-blind Program to Evaluate Efficacy and Safety of Upadacitinib in Adult and Adolescent Subjects With Severe Alopecia Areata",
"has_exemption": false,
"start_date": "2023-10-11",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06159673",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06159673",
"title": "A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer's Disease Psychosis",
"has_exemption": false,
"start_date": "2023-11-14",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "ACADIA Pharmaceuticals Inc.",
"sponsor_slug": "acadia-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05872204",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05872204",
"title": "A Phase II, Open-label, Multicenter Study of Abemaciclib and Letrozole in Patients With Estrogen Receptor-positive Rare Ovarian Cancer",
"has_exemption": false,
"start_date": "2023-11-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Universitaire Ziekenhuizen KU Leuven",
"sponsor_slug": "universitaire-ziekenhuizen-ku-leuven",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06111235",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06111235",
"title": "A Phase 3, Randomized Study of Adjuvant Cretostimogene Grenadenorepvec Versus Observation for the Treatment of Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR-NMIBC) Following Transurethral Resection of Bladder Tumor (TURBT)",
"has_exemption": false,
"start_date": "2023-12-14",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "CG Oncology, Inc.",
"sponsor_slug": "cg-oncology-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06106295",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06106295",
"title": "Metyrapone Intervention in Patients With Mild Autonomous Cortisol Secretion (MACS)",
"has_exemption": false,
"start_date": "2023-12-19",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06199531",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06199531",
"title": "A Phase 1/2/3 Open-label, Single Arm, Dose-finding Study to Investigate Long-term Safety, Tolerability and Efficacy of GS-100, an Adeno-associated Virus Serotype 9 (AAV9) Vector-mediated Gene Transfer of Human NGLY1, in Patients With NGLY1 Deficiency",
"has_exemption": false,
"start_date": "2024-02-13",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Grace Science, LLC",
"sponsor_slug": "grace-science-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06192758",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06192758",
"title": "An Early Feasibility Study to Evaluate the Safety of the TheraSphere Prostate Cancer (PCa) Device in Patients With Clinically Localized Prostate Cancer",
"has_exemption": false,
"start_date": "2024-04-15",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Boston Scientific Corporation",
"sponsor_slug": "boston-scientific-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06240312",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06240312",
"title": "Optic Nerve Head Strain as Biomarker for Glaucoma",
"has_exemption": false,
"start_date": "2024-07-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Johns Hopkins University",
"sponsor_slug": "johns-hopkins-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06252649",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06252649",
"title": "Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)",
"has_exemption": false,
"start_date": "2024-07-17",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Amgen",
"sponsor_slug": "amgen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05968664",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05968664",
"title": "Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation",
"has_exemption": false,
"start_date": "2024-08-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Ashwin Viswanathan",
"sponsor_slug": "ashwin-viswanathan",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06508658",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06508658",
"title": "A Phase 3, Multicenter, Randomized, Open-Label Study of Epcoritamab Plus Lenalidomide Compared to Rituximab Plus Gemcitabine and Oxaliplatin in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma",
"has_exemption": false,
"start_date": "2024-08-13",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Genmab",
"sponsor_slug": "genmab",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06544733",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06544733",
"title": "An Operationally Seamless Phase 2/3, Randomized, Active-Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of GS-1720 in Combination With GS-4182 Versus Biktarvy in Virologically Suppressed People With HIV-1",
"has_exemption": false,
"start_date": "2024-08-20",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Gilead Sciences",
"sponsor_slug": "gilead-sciences",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05696366",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05696366",
"title": "Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes",
"has_exemption": false,
"start_date": "2024-09-09",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Diego",
"sponsor_slug": "university-of-california-san-diego",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06525220",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06525220",
"title": "A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Recurrent or Metastatic PD-L1+ Head and Neck Squamous Cell Carcinoma",
"has_exemption": false,
"start_date": "2024-09-25",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Merus N.V.",
"sponsor_slug": "merus-nv",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06027099",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06027099",
"title": "Integrating Tailored Postoperative Opioid Tapering and Pain Management Support for Patients on Long-Term Opioid Use Presenting for Spine Surgery",
"has_exemption": false,
"start_date": "2024-09-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06494631",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06494631",
"title": "Clinical Study to Assess the Safety and Performance of the Xeltis Hemodialysis Access Graft",
"has_exemption": false,
"start_date": "2024-11-11",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Xeltis",
"sponsor_slug": "xeltis",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06763315",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06763315",
"title": "The Efficacy, Safety, and Long-Term Prognosis of Low-Dose Selumetinib in the Treatment of Neurofibromatosis Type 1 Associated Plexiform Neurofibromas in Chinese Children: a Multicenter Randomized Controlled Trial",
"has_exemption": false,
"start_date": "2025-01-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "West China Hospital",
"sponsor_slug": "west-china-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06807359",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06807359",
"title": "Open-label Clinical Phase 1/2 Study to Assess the Safety and Efficacy of the SpectraCure P18 System and Verteporfin for Injection for the Treatment of Primary Localized Prostate Cancer",
"has_exemption": false,
"start_date": "2025-01-06",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "SpectraCure AB",
"sponsor_slug": "spectracure-ab",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06773195",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06773195",
"title": "A Phase 1/2 Study of Combined JAK/ERK Inhibition in Patients With Myelofibrosis",
"has_exemption": false,
"start_date": "2025-01-07",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06504381",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06504381",
"title": "A Phase I/IIa Study to Evaluate the Efficacy of DB107-RRV (Formerly Toca511), Administered to Subjects at Time of Resection and Intravenously Thereafter, in Combination With DB107-FC (Formerly Toca FC) and Radiation Therapy or DB107-FC, Temozolomide (TMZ) and Radiation Therapy in Patients With Newly Diagnosed High Grade Glioma",
"has_exemption": false,
"start_date": "2025-01-08",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Francisco",
"sponsor_slug": "university-of-california-san-francisco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06743126",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06743126",
"title": "A Prospective, Multicenter, Open-label, Randomized, Actively Controlled, Parallel-group Phase 3 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of IMA203 Versus Investigator's Choice of Treatment in Patients With Previously Treated, Unresectable or Metastatic Cutaneous Melanoma (ACTengine® IMA203-301)",
"has_exemption": false,
"start_date": "2025-01-14",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Immatics US, Inc.",
"sponsor_slug": "immatics-us-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06765317",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06765317",
"title": "Optimizing Frontline Therapy for DLBCL in Older Adults: A GLOfitamab-based, Response-adapted, Window-stYle Study (GLORY)",
"has_exemption": false,
"start_date": "2025-01-16",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06726122",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06726122",
"title": "Clinical Study to Evaluate the Efficacy and Safety of Matrix Pro Treatment for Facial, Submental and Neck Laxity",
"has_exemption": false,
"start_date": "2025-01-28",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Candela Corporation",
"sponsor_slug": "candela-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06478017",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06478017",
"title": "Belatacept With Delayed Tacrolimus Withdrawal Versus Standard-of-Care Tacrolimus in Heart Transplant Recipients (RTB-013)",
"has_exemption": false,
"start_date": "2025-01-29",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "National Institute of Allergy and Infectious Diseases (NIAID)",
"sponsor_slug": "national-institute-of-allergy-and-infectious-diseases-niaid",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06672575",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06672575",
"title": "A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma",
"has_exemption": false,
"start_date": "2025-01-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06697314",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06697314",
"title": "Prospective, Multicenter, Multi-national, Single Arm Trial Evaluating the Efficacy, Safety and Long Term Functional Outcomes of Percutaneous Mechanical Aspiration Thrombectomy for Treatment of Acute Pulmonary Embolism Using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System",
"has_exemption": false,
"start_date": "2025-01-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Angiodynamics, Inc.",
"sponsor_slug": "angiodynamics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06854653",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06854653",
"title": "An Open-Label, Phase 2 Study of PTX-100 Monotherapy in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma.",
"has_exemption": false,
"start_date": "2025-03-28",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Prescient Therapeutics, Ltd.",
"sponsor_slug": "prescient-therapeutics-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06470282",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06470282",
"title": "Phase Ib/II Study of Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy as a Bladder-Sparing Trimodality Therapy in Muscle Invasive Bladder Cancer",
"has_exemption": false,
"start_date": "2025-03-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, San Francisco",
"sponsor_slug": "university-of-california-san-francisco",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06865105",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06865105",
"title": "A Phase 2 Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Active Psoriatic Arthritis",
"has_exemption": false,
"start_date": "2025-04-11",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06710756",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06710756",
"title": "A Phase I/IIa Image-Guided, Alpha-Particle Therapy Study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in Patients With Solid Tumors That Are Known to be Fibroblast Activation Protein (FAP)-Positive",
"has_exemption": false,
"start_date": "2025-04-28",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Perspective Therapeutics",
"sponsor_slug": "perspective-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06847360",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06847360",
"title": "Home-Based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Pain and Symptom Management Among Young Adults With Irritable Bowel Syndrome (IBS)",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Yale University",
"sponsor_slug": "yale-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06914765",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06914765",
"title": "A Pilot Study Evaluating the Safety and Efficacy of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adolescents",
"has_exemption": false,
"start_date": "2025-05-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Children's Hospital of Philadelphia",
"sponsor_slug": "childrens-hospital-of-philadelphia",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06699836",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06699836",
"title": "A Phase Two Study Evaluating Two Doses of Leronlimab (Pro 140) In Combination With Trifluridine + Tipiracil (TAS-102) + Bevacizumab in Participants With CCR5+, Microsatellite Stable (MSS), Relapsed Refractory Metastatic Colorectal Cancer (mCRC)",
"has_exemption": false,
"start_date": "2025-06-16",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "CytoDyn, Inc.",
"sponsor_slug": "cytodyn-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06991114",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06991114",
"title": "An Open-label Phase 2a Study to Evaluate the Safety and Efficacy of AlloNK®, an Allogeneic Cord Blood-derived NK Cell Therapy, in Combination With Rituximab in Relapsing Forms of B-cell Dependent Rheumatologic Diseases",
"has_exemption": false,
"start_date": "2025-06-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Artiva Biotherapeutics, Inc.",
"sponsor_slug": "artiva-biotherapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06904378",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06904378",
"title": "Phase I/II Clinical Trial of Ontegimod and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma: Reprogramming Tumor-associated Myeloid Cells",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06801015",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06801015",
"title": "A Randomized, Placebo-Controlled Trial of the Effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastric Motor Functions",
"has_exemption": false,
"start_date": "2025-08-15",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Mayo Clinic",
"sponsor_slug": "mayo-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06855043",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06855043",
"title": "Pilot Study of Late Surfactant Therapy With Budesonide for Prevention of Bronchopulmonary Dysplasia in Extremely Preterm Infants",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Wisconsin, Madison",
"sponsor_slug": "university-of-wisconsin-madison",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05361915",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05361915",
"title": "A Phase 2 Study of AbiVERtinib in Combination With Abiraterone in Patients With Metastatic Castration Resistant Prostate Cancer (Maverick Trial)",
"has_exemption": false,
"start_date": "2025-09-30",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Sorrento Therapeutics, Inc.",
"sponsor_slug": "sorrento-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06973668",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06973668",
"title": "A Randomized Study to Compare Post-transplant Cyclophosphamide, Sirolimus, Ruxolitinib and Post-transplant Cyclophosphamide, Sirolimus, Mycophenolate Mofetil to Prevent Graft Versus Host Disease",
"has_exemption": false,
"start_date": "2025-10-01",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06716021",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06716021",
"title": "Multi-Center, Placebo-Controlled, Phase 3 Study of Etripamil Nasal Spray (NS) in Patients With Atrial Fibrillation and Rapid Ventricular Rate (RVR)",
"has_exemption": false,
"start_date": "2026-01-31",
"completion_date": "2028-01-31",
"has_results": false,
"results_due": false,
"sponsor_name": "Milestone Pharmaceuticals Inc.",
"sponsor_slug": "milestone-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05949099",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05949099",
"title": "Phase II Study of Cryoablation and Nirogacestat for Desmoid Tumor",
"has_exemption": false,
"start_date": "2023-08-15",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Nam Bui",
"sponsor_slug": "nam-bui",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05819853",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05819853",
"title": "Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome",
"has_exemption": false,
"start_date": "2023-11-03",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Colorado, Denver",
"sponsor_slug": "university-of-colorado-denver",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05386394",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05386394",
"title": "Phase II Clinical Trial of Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia",
"has_exemption": false,
"start_date": "2024-02-13",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Johns Hopkins University",
"sponsor_slug": "johns-hopkins-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06174038",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06174038",
"title": "Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess the Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer's Disease and Related Dementias",
"has_exemption": false,
"start_date": "2024-04-01",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Columbia University",
"sponsor_slug": "columbia-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06127407",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06127407",
"title": "A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Study of Ivosidenib in Participants ≥18 Years of Age With Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen",
"has_exemption": false,
"start_date": "2024-07-09",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Servier Bio-Innovation LLC",
"sponsor_slug": "servier-bio-innovation-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06336655",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06336655",
"title": "Physiology of Unloading VA ECMO Trial",
"has_exemption": false,
"start_date": "2024-10-02",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Utah",
"sponsor_slug": "university-of-utah",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06867549",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06867549",
"title": "Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II",
"has_exemption": false,
"start_date": "2025-03-04",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04433572",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04433572",
"title": "Temsirolimus Adventitial Delivery to Improve ANGioplasty And/or Atherectomy Revascularization Outcomes Below the Knee: a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Temsirolimus Perivascular Injection 0.1 Mg/mL on the Incidence of Ischemia-Driven Major Amputation, Clinically Driven Target Lesion Revascularization, and Clinically Relevant Target Lesion Occlusion After Revascularization of Lesions Below the Knee in Patients with Symptomatic Rutherford 3-5 Peripheral Artery Disease",
"has_exemption": false,
"start_date": "2025-04-30",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Mercator MedSystems, Inc.",
"sponsor_slug": "mercator-medsystems-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06940180",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06940180",
"title": "Perioperative Chemoimmunotherapy With Toripalimab for Sinonasal Cancer",
"has_exemption": false,
"start_date": "2025-06-17",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Glenn J. Hanna",
"sponsor_slug": "glenn-j-hanna",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07085338",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07085338",
"title": "A Phase II Study With a Safety Run-In of the Addition of N-803, a Novel IL-15 Super-Agonist, to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "St. Jude Children's Research Hospital",
"sponsor_slug": "st-jude-childrens-research-hospital",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06445166",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06445166",
"title": "A Multicenter Phase II Study of Propranolol for the Treatment of Kaposi Sarcoma in Adults",
"has_exemption": false,
"start_date": "2025-08-31",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07009899",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07009899",
"title": "BCMA Bispecific Antibody Therapy for Post-BCMA CAR T-Cell Therapy Relapse (RECLAIM)",
"has_exemption": false,
"start_date": "2025-09-01",
"completion_date": "2028-02-01",
"has_results": false,
"results_due": false,
"sponsor_name": "Medical College of Wisconsin",
"sponsor_slug": "medical-college-of-wisconsin",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03173924",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03173924",
"title": "Evaluation of 18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer",
"has_exemption": false,
"start_date": "2017-06-06",
"completion_date": "2028-02-06",
"has_results": false,
"results_due": false,
"sponsor_name": "National Cancer Institute (NCI)",
"sponsor_slug": "national-cancer-institute-nci",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06989437",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06989437",
"title": "A PHASE 2b/3, RANDOMIZED, DOUBLE-BLIND STUDY TO INVESTIGATE THE EFFICACY, SAFETY, AND TOLERABILITY OF PONSEGROMAB (PF-06946860) COMPARED WITH PLACEBO BOTH WITH BACKGROUND FIRST-LINE CHEMOTHERAPY IN ADULT PARTICIPANTS WITH CACHEXIA AND METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA",
"has_exemption": false,
"start_date": "2025-08-29",
"completion_date": "2028-02-06",
"has_results": false,
"results_due": false,
"sponsor_name": "Pfizer",
"sponsor_slug": "pfizer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04771130",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04771130",
"title": "A Phase 1b/2, Open-Label, Dose Finding, and Expansion Study of the Bcl-2 Inhibitor BGB-11417 in Patients With Myeloid Malignancies",
"has_exemption": false,
"start_date": "2021-05-24",
"completion_date": "2028-02-08",
"has_results": false,
"results_due": false,
"sponsor_name": "BeiGene",
"sponsor_slug": "beigene",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04266041",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04266041",
"title": "High-density EEG in Neurological Disorders",
"has_exemption": false,
"start_date": "2018-02-09",
"completion_date": "2028-02-09",
"has_results": false,
"results_due": false,
"sponsor_name": "Dartmouth-Hitchcock Medical Center",
"sponsor_slug": "dartmouth-hitchcock-medical-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06456463",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06456463",
"title": "A Phase II Multicenter Open-label Trial of Tagraxofusp (Tag) in Combination With Venetoclax and Azacitidine (Ven/Aza) in Adults With Previously Untreated CD123+ Acute Myeloid Leukemia (AML) Who Are Ineligible for Intensive Chemotherapy",
"has_exemption": false,
"start_date": "2025-01-14",
"completion_date": "2028-02-09",
"has_results": false,
"results_due": false,
"sponsor_name": "Stemline Therapeutics, Inc.",
"sponsor_slug": "stemline-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06331312",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06331312",
"title": "A Multi-center, Open-label Extension Study of Subcutaneous Secukinumab to Evaluate the Long-term Safety and Tolerability in Polymyalgia Rheumatica (PMR)",
"has_exemption": false,
"start_date": "2024-06-28",
"completion_date": "2028-02-10",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06525636",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06525636",
"title": "A Multicenter, Open-label, Phase 1/2, Dose-escalation and Subsequent Safety Extension Study of Subcutaneous KK8123 in Adult Patients With X-linked Hypophosphatemia",
"has_exemption": false,
"start_date": "2024-10-09",
"completion_date": "2028-02-11",
"has_results": false,
"results_due": false,
"sponsor_name": "Kyowa Kirin Co., Ltd.",
"sponsor_slug": "kyowa-kirin-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06979323",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06979323",
"title": "The IMAGINE Study: A Phase 3b Open Label, Single Arm Study to Assess the Effect of Depemokimab on Airway Structure and Function in Asthma With Type 2 Inflammation Characterized by an Eosinophilic Phenotype Utilizing Quantitative High-resolution CT and Bronchoscopic Airway Sampling in a Sub Study",
"has_exemption": false,
"start_date": "2025-06-03",
"completion_date": "2028-02-11",
"has_results": false,
"results_due": false,
"sponsor_name": "GlaxoSmithKline",
"sponsor_slug": "glaxosmithkline",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05201066",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05201066",
"title": "An Open-label, Multicenter, Roll-over Study for Patients Who Have Completed a Prior Novartis-sponsored Sabatolimab (MBG453) Study and Are Judged by the Investigator to Benefit From Continued Treatment With Sabatolimab.",
"has_exemption": false,
"start_date": "2023-02-13",
"completion_date": "2028-02-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06311721",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06311721",
"title": "A Randomized, Double-Blind Study to Compare Efficacy, Pharmacokinetics, Safety, and Immunogenicity Between ABP 234 and Keytruda® (Pembrolizumab) in Subjects With Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer",
"has_exemption": false,
"start_date": "2024-09-09",
"completion_date": "2028-02-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Amgen",
"sponsor_slug": "amgen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06542250",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06542250",
"title": "A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With Relapsed or Refractory B-Cell Malignancies (TITANium)",
"has_exemption": false,
"start_date": "2024-09-18",
"completion_date": "2028-02-14",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07047118",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07047118",
"title": "A Phase II, Randomized, Open-label, Multi-center Study of JSB462 (Luxdegalutamide) in Combination With Lutetium (177Lu) Vipivotide Tetraxetan in Adult Male Patients With PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC)",
"has_exemption": false,
"start_date": "2025-07-03",
"completion_date": "2028-02-14",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03974113",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03974113",
"title": "ATLAS-PEDS: An Open-label, Multinational Study of Fitusiran Prophylaxis in Male Pediatric Subjects Aged 1 to Less Than 12 Years With Hemophilia A or B",
"has_exemption": false,
"start_date": "2020-01-28",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Genzyme, a Sanofi Company",
"sponsor_slug": "genzyme-a-sanofi-company",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04524611",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04524611",
"title": "A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF Therapy",
"has_exemption": false,
"start_date": "2020-09-30",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "AbbVie",
"sponsor_slug": "abbvie",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05363709",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05363709",
"title": "A Phase 2 Study to Assess the Effect of BALSTILIMAB (AGEN2034) on Viral Clearance in HPV-positive Oropharyngeal Cancer Patients With Persistent HPV Detection in Plasma cfDNA After Definitive Therapy",
"has_exemption": false,
"start_date": "2023-10-18",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06253221",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06253221",
"title": "A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adolescents (Age 12 Years to < 18 Years) With Symptomatic Obstructive Hypertrophic Cardiomyopathy",
"has_exemption": false,
"start_date": "2024-04-17",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Bristol-Myers Squibb",
"sponsor_slug": "bristol-myers-squibb",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06747585",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06747585",
"title": "A Phase I/II, Open-Label, Multicenter Study of ALE.P02 (Claudin-1 Targeted Antibody-Drug Conjugate) as a Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+Squamous Solid Tumors",
"has_exemption": false,
"start_date": "2024-12-16",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Alentis Therapeutics AG",
"sponsor_slug": "alentis-therapeutics-ag",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06948448",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06948448",
"title": "A Randomized, Open Label, Multicenter, Phase 2 Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo® in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care for First-line Treatment of Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2028-02-15",
"has_results": false,
"results_due": false,
"sponsor_name": "Ono Pharmaceutical Co. Ltd",
"sponsor_slug": "ono-pharmaceutical-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06706622",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06706622",
"title": "Interventional, Randomized, Double-blind, Placebo-controlled, Optional Open-label Extension Trial of Lu AF82422 in Participants With Multiple System Atrophy",
"has_exemption": false,
"start_date": "2024-12-03",
"completion_date": "2028-02-17",
"has_results": false,
"results_due": false,
"sponsor_name": "H. Lundbeck A/S",
"sponsor_slug": "h-lundbeck-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06627244",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06627244",
"title": "Phase 2, Single Arm Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma",
"has_exemption": false,
"start_date": "2025-02-14",
"completion_date": "2028-02-17",
"has_results": false,
"results_due": false,
"sponsor_name": "University of Miami",
"sponsor_slug": "university-of-miami",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07007793",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07007793",
"title": "A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Baxdrostat in Adult Participants With Primary Aldosteronism",
"has_exemption": false,
"start_date": "2025-08-07",
"completion_date": "2028-02-18",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06843434",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06843434",
"title": "A Phase II Study of Neoadjuvant Botensilimab and Balstilimab Immunotherapy for Mismatch Repair Proficient Rectal Adenocarcinoma",
"has_exemption": false,
"start_date": "2025-02-20",
"completion_date": "2028-02-20",
"has_results": false,
"results_due": false,
"sponsor_name": "Memorial Sloan Kettering Cancer Center",
"sponsor_slug": "memorial-sloan-kettering-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06439485",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06439485",
"title": "Phase I/II Trial of Pemigatinib in Combination With Atezolizumab and Bevacizumab for Treatment of Advanced Cholangiocarcinoma With FGFR2 Fusion",
"has_exemption": false,
"start_date": "2024-11-19",
"completion_date": "2028-02-22",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06668181",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06668181",
"title": "Open-Label, Single-Arm Trial to Evaluate the Pharmacokinetics and Safety of Bimekizumab in Pediatric Study Participants From 2 to Less Than 18 Years of Age With Active Juvenile Idiopathic Arthritis Subtypes Enthesitis-Related Arthritis (Including Juvenile-Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis",
"has_exemption": false,
"start_date": "2025-03-11",
"completion_date": "2028-02-22",
"has_results": false,
"results_due": false,
"sponsor_name": "UCB Biopharma SRL",
"sponsor_slug": "ucb-biopharma-srl",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04083495",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04083495",
"title": "Phase II Study of the Administration of T Lymphocytes Expressing the CD30 Chimeric Antigen Receptor (CAR) for Relapsed/Refractory CD30+ Peripheral T Cell Lymphoma",
"has_exemption": false,
"start_date": "2019-09-17",
"completion_date": "2028-02-23",
"has_results": false,
"results_due": false,
"sponsor_name": "UNC Lineberger Comprehensive Cancer Center",
"sponsor_slug": "unc-lineberger-comprehensive-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04782258",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04782258",
"title": "A Phase 3b Multicenter Open-label Trial of the Safety, Tolerability, and Efficacy of Tolvaptan in Infants and Children 28 Days to Less Than 18 Years of Age With Autosomal Recessive Polycystic Kidney Disease (ARPKD)",
"has_exemption": false,
"start_date": "2022-07-15",
"completion_date": "2028-02-23",
"has_results": false,
"results_due": false,
"sponsor_name": "Otsuka Pharmaceutical Development & Commercialization, Inc.",
"sponsor_slug": "otsuka-pharmaceutical-development-commercialization-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06866405",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06866405",
"title": "A Phase 3 Study to Investigate the Safety, Tolerability, and Immunogenicity of Revaccinating Pregnant Participants During Subsequent Pregnancies and Persistence of Immunity of a Single Dose of a Bivalent Respiratory Syncytial Virus (RSV) Vaccine.",
"has_exemption": false,
"start_date": "2025-04-16",
"completion_date": "2028-02-24",
"has_results": false,
"results_due": false,
"sponsor_name": "Pfizer",
"sponsor_slug": "pfizer",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06744920",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06744920",
"title": "A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Remibrutinib in Patients With Generalized Myasthenia Gravis, Followed by an Open-label Extension Phase",
"has_exemption": false,
"start_date": "2025-02-07",
"completion_date": "2028-02-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Novartis Pharmaceuticals",
"sponsor_slug": "novartis-pharmaceuticals",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07096908",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07096908",
"title": "Treatment With Tirzepatide of the Disease of Obesity in People With Type 1 Diabetes",
"has_exemption": false,
"start_date": "2025-07-31",
"completion_date": "2028-02-25",
"has_results": false,
"results_due": false,
"sponsor_name": "Dasman Diabetes Institute",
"sponsor_slug": "dasman-diabetes-institute",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT03887715",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03887715",
"title": "A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression",
"has_exemption": false,
"start_date": "2019-09-26",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "LivaNova",
"sponsor_slug": "livanova",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04610866",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04610866",
"title": "Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat",
"has_exemption": false,
"start_date": "2020-12-09",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "National Heart, Lung, and Blood Institute (NHLBI)",
"sponsor_slug": "national-heart-lung-and-blood-institute-nhlbi",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04774718",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04774718",
"title": "A Phase I/II, Open-Label, Multicenter, Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors for Whom Prior Treatment Has Proven to be Ineffective or for Whom There is No Satisfactory Treatment Available",
"has_exemption": false,
"start_date": "2021-09-14",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04931342",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04931342",
"title": "A Phase II, Open-Label, Multicenter, Platform Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors",
"has_exemption": false,
"start_date": "2021-10-07",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Hoffmann-La Roche",
"sponsor_slug": "hoffmann-la-roche",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04712539",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04712539",
"title": "Efficacy of Combination Baloxovir and Oseltamivir Therapy in Influenza Infected Immunocompromised Hosts",
"has_exemption": false,
"start_date": "2021-10-11",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05064280",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05064280",
"title": "Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases",
"has_exemption": false,
"start_date": "2022-01-20",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "M.D. Anderson Cancer Center",
"sponsor_slug": "md-anderson-cancer-center",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04966481",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04966481",
"title": "Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor: A Multicenter, Open-Label, Randomized Phase 3 Trial",
"has_exemption": false,
"start_date": "2022-04-06",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Washington University School of Medicine",
"sponsor_slug": "washington-university-school-of-medicine",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05713253",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05713253",
"title": "A PHASED, PROSPECTIVE, MULTI-CENTER STUDY OF THE ELITA SYSTEM FOR THE REDUCTION OR ELIMINATION OF MYOPIC REFRACTIVE ERRORS WITH OR WITHOUT ASTIGMATISM",
"has_exemption": false,
"start_date": "2023-02-02",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Johnson & Johnson Surgical Vision, Inc.",
"sponsor_slug": "johnson-johnson-surgical-vision-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05594992",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05594992",
"title": "An Extension Study of JR-141 to Evaluate the Long-term Safety and Efficacy in Mucopolysaccharidosis Type II (Hunter Syndrome) Subjects",
"has_exemption": false,
"start_date": "2023-02-22",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "JCR Pharmaceuticals Co., Ltd.",
"sponsor_slug": "jcr-pharmaceuticals-co-ltd",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05816382",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05816382",
"title": "A Long-term Extension Study to Evaluate the Safety and Tolerability of TAK-861 in Participants With Selected Central Hypersomnia Conditions",
"has_exemption": false,
"start_date": "2023-04-05",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Takeda",
"sponsor_slug": "takeda",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05546554",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05546554",
"title": "Randomized Placebo-Controlled Crossover Trial of Suvorexant for Sleep in Children With Autism",
"has_exemption": false,
"start_date": "2023-08-09",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06331052",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06331052",
"title": "3-D Tractography Focused Ultrasound Ablation for Essential Tremor",
"has_exemption": false,
"start_date": "2024-02-28",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "University of North Carolina, Chapel Hill",
"sponsor_slug": "university-of-north-carolina-chapel-hill",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06964269",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06964269",
"title": "A Phase 4 Pilot Study With Extension to Assess the Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease and the Effect on Corneal Nerves and Neuropathic Corneal Pain",
"has_exemption": false,
"start_date": "2025-02-11",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Toyos Clinic",
"sponsor_slug": "toyos-clinic",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06831149",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06831149",
"title": "A Phase 2 Trial of Intraoperative Fluorescent Angiography to Decrease Pharyngocutaneous Fistula Rates in Patients Undergoing Hypopharyngeal Reconstruction",
"has_exemption": false,
"start_date": "2025-02-28",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Matthew Spector",
"sponsor_slug": "matthew-spector",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06855498",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06855498",
"title": "A Phase 3b, Multicenter, Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib",
"has_exemption": false,
"start_date": "2025-02-28",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Incyte Corporation",
"sponsor_slug": "incyte-corporation",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06817018",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06817018",
"title": "Ginger and the Microbiota-gut-brain Connection in Sciatic Pain Individuals",
"has_exemption": false,
"start_date": "2025-03-01",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Leslie Shen",
"sponsor_slug": "leslie-shen",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06810375",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06810375",
"title": "Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery",
"has_exemption": false,
"start_date": "2025-03-01",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "George Washington University",
"sponsor_slug": "george-washington-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06795022",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06795022",
"title": "A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD9793, a T Cell-engaging Antibody Targeting Glypican-3 (GPC3) in Adult Participants With Advanced or Metastatic Solid Tumours (RHEA-1)",
"has_exemption": false,
"start_date": "2025-03-27",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "AstraZeneca",
"sponsor_slug": "astrazeneca",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06819670",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06819670",
"title": "A Multicenter Pilot Clinical Trial to Prevent Infantile Spasms Relapse",
"has_exemption": false,
"start_date": "2025-05-05",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "University of California, Los Angeles",
"sponsor_slug": "university-of-california-los-angeles",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT07048262",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT07048262",
"title": "A Phase 2b, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled, Dose Range Finding Study to Evaluate the Efficacy, Safety, and Tolerability of Nebulized CSL787 in Adults (18 to 85 Years) With Non-cystic Fibrosis Bronchiectasis",
"has_exemption": false,
"start_date": "2025-07-27",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "CSL Behring",
"sponsor_slug": "csl-behring",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04883619",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04883619",
"title": "A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Nipocalimab in Adult Participants With Active Lupus Nephritis",
"has_exemption": false,
"start_date": "2026-01-15",
"completion_date": "2028-02-28",
"has_results": false,
"results_due": false,
"sponsor_name": "Janssen Research & Development, LLC",
"sponsor_slug": "janssen-research-development-llc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT02679144",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT02679144",
"title": "NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)",
"has_exemption": false,
"start_date": "2016-02-29",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Giselle Sholler",
"sponsor_slug": "giselle-sholler",
"status": "ongoing",
"is_pact": true,
"days_late": null
},
{
"registry_id": "NCT03093116",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT03093116",
"title": "A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)",
"has_exemption": false,
"start_date": "2017-03-07",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Turning Point Therapeutics, Inc.",
"sponsor_slug": "turning-point-therapeutics-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05130450",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05130450",
"title": "An Open-Label Extension Study of AKCEA-APOCIII-LRx Administered Subcutaneously to Patients With Familial Chylomicronemia Syndrome (FCS)",
"has_exemption": false,
"start_date": "2021-11-18",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Ionis Pharmaceuticals, Inc.",
"sponsor_slug": "ionis-pharmaceuticals-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04925544",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04925544",
"title": "Phase 2, Open-label, Clinical Trial of a Novel Small Molecule EBNA1 Inhibitor, VK 2019, in Patients With Epstein Barr Virus Positive Nasopharyngeal Cancer (NPC) and Other EBV-associated Cancers, With Pharmacokinetic and Pharmacodynamic Correlative Studies",
"has_exemption": false,
"start_date": "2022-01-25",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Stanford University",
"sponsor_slug": "stanford-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05215340",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05215340",
"title": "A Randomized, Open-label, Phase 3 Trial of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in Treatment-naïve Subjects With Advanced or Metastatic PD-L1 High (TPS ≥50%) Non-small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung08)",
"has_exemption": false,
"start_date": "2022-03-04",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Daiichi Sankyo",
"sponsor_slug": "daiichi-sankyo",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05294588",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05294588",
"title": "Division of Microbiology and Infectious Diseases, (DMID) 21-0018: Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae",
"has_exemption": false,
"start_date": "2022-04-18",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "University of North Carolina, Chapel Hill",
"sponsor_slug": "university-of-north-carolina-chapel-hill",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05135091",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05135091",
"title": "A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX- 1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)",
"has_exemption": false,
"start_date": "2022-06-16",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Neurona Therapeutics",
"sponsor_slug": "neurona-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05529316",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05529316",
"title": "A Multicohort, Open Label, Phase 2 Study of Botensilimab (AGEN1181) for Treatment of Advanced Melanoma Refractory to Prior Checkpoint Inhibitor Therapy",
"has_exemption": false,
"start_date": "2022-12-12",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Agenus Inc.",
"sponsor_slug": "agenus-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT04905914",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT04905914",
"title": "A Phase 1/2a, Open-Label, Safety, Pharmacokinetic, And Preliminary Efficacy Study Of Oral ATRN-119 In Patients With Advanced Solid Tumors",
"has_exemption": false,
"start_date": "2023-01-09",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Aprea Therapeutics",
"sponsor_slug": "aprea-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05783609",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05783609",
"title": "A Phase 2 Study of Epcoritamab and Rituximab for First-line Treatment of Follicular Lymphoma",
"has_exemption": false,
"start_date": "2023-06-21",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Reid Merryman, MD",
"sponsor_slug": "reid-merryman-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05930561",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05930561",
"title": "A Phase 2 Randomized, Active-Controlled, Double-masked Trial of Intravitreal 4D-150 Gene Therapy in Adults With Diabetic Macular Edema (SPECTRA)",
"has_exemption": false,
"start_date": "2023-08-09",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "4D Molecular Therapeutics",
"sponsor_slug": "4d-molecular-therapeutics",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05537896",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05537896",
"title": "Prospective Evaluation of Xerava™ (Eravacycline) Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia",
"has_exemption": false,
"start_date": "2024-02-19",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "West Virginia University",
"sponsor_slug": "west-virginia-university",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06260709",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06260709",
"title": "Open-label Extension Study of Long-term Safety and Efficacy of NNC6019-0001 in Participants With Transthyretin Amyloid Cardiomyopathy (ATTR CM)",
"has_exemption": false,
"start_date": "2024-02-20",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Novo Nordisk A/S",
"sponsor_slug": "novo-nordisk-as",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT05913388",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT05913388",
"title": "Randomized Double-Blind Placebo Controlled Phase II Study of a Galectin-3 Inhibitor (GB1211) and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma",
"has_exemption": false,
"start_date": "2024-02-29",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Providence Health & Services",
"sponsor_slug": "providence-health-services",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06191562",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06191562",
"title": "Randomized Clinical Trial of Post-operative Outcomes Following Posterior Versus Anterior Tympanostomy Tube Placement",
"has_exemption": false,
"start_date": "2024-02-29",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "David Chi, MD",
"sponsor_slug": "david-chi-md",
"status": "ongoing",
"is_pact": false,
"days_late": null
},
{
"registry_id": "NCT06228326",
"publication_url": "https://clinicaltrials.gov/ct2/show/NCT06228326",
"title": "KB707-02: A Phase 1/2 Study of Inhaled KB707 in Patients With Advanced Solid Tumor Malignancies Affecting the Lungs",
"has_exemption": false,
"start_date": "2024-04-17",
"completion_date": "2028-02-29",
"has_results": false,
"results_due": false,
"sponsor_name": "Krystal Biotech, Inc.",
"sponsor_slug": "krystal-biotech-inc",
"status": "ongoing",
"is_pact": false,
"days_late": null
}
]
}